Results 201 to 210 of about 54,523 (223)
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2015
In metazoa, inductive cell-to-cell interactions play crucial roles, both in embryonic development and in homeostasis. Many such interactions are mediated by RTKs and their soluble or surface-bound ligand growth factors. Type 1 RTKs, also called the ERBB or HER family, comprises four proteins, which bind growth factors of the EGF and neuregulin families.
Fresia Pareja, Gur Pines, Yosef Yarden
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In metazoa, inductive cell-to-cell interactions play crucial roles, both in embryonic development and in homeostasis. Many such interactions are mediated by RTKs and their soluble or surface-bound ligand growth factors. Type 1 RTKs, also called the ERBB or HER family, comprises four proteins, which bind growth factors of the EGF and neuregulin families.
Fresia Pareja, Gur Pines, Yosef Yarden
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Neuregulins and ErbB receptors in cultured neonatal astrocytes
Journal of Neuroscience Research, 1999Neuregulins (NRGs) are a family of growth factors involved in signaling between neurons and glial cells of the peripheral and central nervous system. NRGs are synthesized and secreted by a number of cell types including Schwann cells, neurons, and oligodendrocytes.
A, Francis +3 more
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1995
Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
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Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
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Localization and modulation of ErbB receptor tyrosine kinases
Current Opinion in Cell Biology, 2001The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling.
K L, Carraway, C, Sweeney
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EGF/ErbB Receptor Family in Ovarian Cancer
2002In summary, the EGF/ErbB family of receptor tyrosine kinases has been shown to play a key role in normal ovarian follicle development, and cell growth regulation of the ovarian surface epithelium. Disregulation of these normal growth regulatory pathways, including overexpression and/or mutation of EGFR/ErbB receptor family members, as well as elements ...
N J, Maihle +12 more
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Trafficking of the ErbB receptors and its influence on signaling
Experimental Cell Research, 2003Although members of the ErbB receptor family are found predominantly at the cell surface, these receptors undergo constant cycling between the plasma membrane and the endosomal compartment. In the absence of an activating ligand, these receptors are slowly internalized (t(1/2) approximately 30 min) but are quickly recycled. The constitutive degradation
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The erbB gene and the EGF receptor.
Cancer surveys, 1987The epidermal growth factor (EGF) receptor is a plasma membrane glycoprotein. It contains four distinct segments: an N-terminal EGF binding domain which is exposed at the cell surface; a short transmembrane segment; a cytoplasmic domain with protein-tyrosine kinase activity; and a C-terminal regulatory segment.
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Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer: A Review
Current Pharmaceutical Biotechnology, 2022Ankita Sahu +2 more
exaly
Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer
Biomedicines, 2023Antonio Villalobo
exaly