Results 191 to 200 of about 36,079 (213)

The status and role of ErbB receptors in human cancer

Experimental and Molecular Pathology, 2008
Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands,
I, Uberall, Z, Kolár, R, Trojanec, J, Berkovcová, M, Hajdúch   +4 more
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Neu/ErbB-2 Receptor

1995
Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
openaire   +1 more source

Localization and modulation of ErbB receptor tyrosine kinases

Current Opinion in Cell Biology, 2001
The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling.
K L, Carraway, C, Sweeney
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Signal transduction and oncogenesis by ErbB/HER receptors

International Journal of Radiation Oncology*Biology*Physics, 2004
Growth factors enable cells to escape irradiation-induced death (apoptosis). One important family of growth factors share an epidermal growth factor motif, and all bind to ErbB transmembrane receptors. In response to growth factor ligands, ErbB receptor tyrosine kinases induce a variety of cellular responses, including proliferation, differentiation ...
Mina D, Marmor, Kochupurakkal Bose, Skaria, Yosef, Yarden   +2 more
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EGF/ErbB Receptor Family in Ovarian Cancer

2002
In summary, the EGF/ErbB family of receptor tyrosine kinases has been shown to play a key role in normal ovarian follicle development, and cell growth regulation of the ovarian surface epithelium. Disregulation of these normal growth regulatory pathways, including overexpression and/or mutation of EGFR/ErbB receptor family members, as well as elements ...
N J, Maihle, A T, Baron, B A, Barrette, C H, Boardman, T A, Christensen, E M, Cora, J M, Faupel-Badger, T, Greenwood, S C, Juneja, J M, Lafky, H, Lee, J L, Reiter, K C, Podratz   +12 more
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Trafficking of the ErbB receptors and its influence on signaling

Experimental Cell Research, 2003
Although members of the ErbB receptor family are found predominantly at the cell surface, these receptors undergo constant cycling between the plasma membrane and the endosomal compartment. In the absence of an activating ligand, these receptors are slowly internalized (t(1/2) approximately 30 min) but are quickly recycled. The constitutive degradation
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The erbB gene and the EGF receptor.

Cancer surveys, 1987
The epidermal growth factor (EGF) receptor is a plasma membrane glycoprotein. It contains four distinct segments: an N-terminal EGF binding domain which is exposed at the cell surface; a short transmembrane segment; a cytoplasmic domain with protein-tyrosine kinase activity; and a C-terminal regulatory segment.
openaire   +1 more source

Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer: A Review

Current Pharmaceutical Biotechnology, 2022
Ankita Sahu, , Manoj Kumar Yadav
exaly  

Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer

Biomedicines, 2023
Antonio Villalobo, Villalobo Antonio
exaly  

ErbB Receptor Family

2006
openaire   +2 more sources