Results 121 to 130 of about 576,050 (220)

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]

Mol Biol Res Commun, 2023
Mashayekh-Poul R, Azimzadeh-Irani M, Masoomi-Nomandan SZ.   +2 more
europepmc   +1 more source

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment.
Dara Bracken‐Clarke, Elisabetta Xue, Harris Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor E. Steuer, Nabil F. Saba, Daniel J. Lubin, Nyall R. London Jr, James L. Gulley, Charalampos S. Floudas   +20 more
wiley   +1 more source

ERBB receptors and cancer: the complexity of targeted inhibitors.

, 2005
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important ...
Lane HA, Hynes NE
core   +1 more source

Binding specificities and affinities of egf domains for ErbB receptors [PDF]

, 1999
ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of ErbB receptors expressed in mammalian cells have helped elucidate specific ...
Sliwkowski, Mark X, Robert W Akita, Jennifer T Jones, Akita, Robert W, Mark X Sliwkowski, Jones, Jennifer T   +5 more
core   +1 more source

Schwann Cells in Physical Nerve Injury and Tumor Perineural Invasion: A Functional Overview and Comparison

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT The nervous system exhibits remarkable stability, making its repair challenging. Compared to the central nervous system, peripheral nerve injuries demonstrate a greater potential for regeneration. Schwann cells, the unique myelinating glial cells of the peripheral nervous system, possess striking plasticity and support nerve regeneration ...
Yanni Zheng, Xin Chen, Jiachen Liu, Jiayi Chen, Lei Tang, Wenjun Liu, Yuxin Lin, Xuedong Wei   +7 more
wiley   +1 more source

The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland

, 2010
We identified the localization and distribution of cell-specific epidermal growth factor receptors (EGFRs erbB-1, erbB-2, erbB-3, erbB-4), vascular endothelial growth factor (VEGF), VEGF receptors [VEGFRs VEGF-R1 (fit-1), VEGF-R2 (flk-1/KDR), VEGF-R3 ...
Hakan Sagsoz, Muzaffer Aydin Ketani, Ketani, Muzaffer Aydin, Sagsoz, Hakan   +3 more
core   +1 more source

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey, Stylianos Kyriakidis, Hilal Khalil, Simon P. Langdon, Harrison, David James, Langdon, Simon P., Bown, James L., Khalil, Hilal S., Simon Langdon, Tero Soininen, Khalil, Hilal S, Soininen, Tero, Alexey Goltsov, Huizhong Hu, David J. Harrison, Bown, James, David Harrison, Deeni, Yusuf, Harrison, David J, Kyriakidis, Stylianos, Hu, Huizhong, Deeni, Yusuf Y.; id_orcid, Yusuf Deeni, Hilal S. Khalil, Langdon, Simon P, James Bown, Harrison, David J.   +26 more
core   +1 more source

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]

Cancers (Basel), 2022
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A.   +9 more
europepmc   +1 more source

Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT AKT (protein kinase B, PKB) coordinates the balance between anabolic and catabolic signaling in skeletal muscle through distinct ubiquitin chain types. Some E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs) form stable binary complexes via non‐catalytic interfaces, adding a regulatory layer unavailable to either enzyme alone.
Rajesh Dabur
wiley   +1 more source