Results 101 to 110 of about 84,102 (243)

Investigating the molecular basic of AMKL and MDS. [PDF]

, 2008
Malignant haematopoiesis is usually associated with various genetic lesions such as chromosomal translocations or mutations in individual genes. This thesis investigates the genetic basis of two such syndromes, acute megakaryoblastic leukaemia (AMKL) and
Salek-Ardakani, S.
core  

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Rent control, rent overcharge, and racial disparity

Real Estate Economics, EarlyView.
Abstract Rent control policies have gained renewed legislative momentum in the United States, but are rent‐regulated landlords adhering to these policies? Answering this question is critical to understanding the policy's impact. Using a unique panel data set from the New York City Housing and Vacancy Survey (NYCHVS), we investigate noncompliance with ...
Brent W. Ambrose, Xun Bian, Ruoyu Chen, Hanchen Jiang   +3 more
wiley   +1 more source

Abstract 30: ERG oncoprotein expression in prostate cancer: Potential for ERG-based stratification

, 2010
Introduction: Prevalent gene fusions involving regulatory sequences of the androgen receptor (AR) regulated prostate associated genes (predominantly TMPRSS2) and protein coding sequences of nuclear transcription factors in the ETS gene family (primarily ...
Gary McMaster, Yongmei Chen, Taduru Sreenath, Ahmed Mohamed, Albert Dobi, Bungo Furusato, Gyorgy Petrovics, Chen Sun, Isabell A. Sesterhenn, Shih-Han Tan, Denise Young, David G. McLeod, Shiv Srivastava, Rajesh Thangapazham   +13 more
core   +1 more source

Renal oxygenation, function and histopathology in an ovine model of heart failure undergoing cardiopulmonary bypass with 48 hours of recovery: a prospective, observational study*

Anaesthesia, EarlyView.
Summary Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models incorporating pre‐existing heart disease.
Anton L. Trask‐Marino, Bruno Marino, Taku Furukawa, Lachlan F. Miles, Jai Raman, Andrew D. Cochrane, Peter R. McCall, Terase F. Lancefield, Roger G. Evans, Ian E. Birchall, Alemayehu H. Jufar, Ashenafi Betrie, Lars I.P. Snel, Munenori Kusunoki, Sally G. Hood, Linda Cornthwaite, Bruce Treagus, Connie Pei Chen Ow, Lindsea C. Booth, Clive N. May, Yugeesh R. Lankadeva   +20 more
wiley   +1 more source

Corrigendum: Improved survival and retinal function of aging ZDF rats in long-term, uncontrolled diabetes by BGP-15 treatment

Frontiers in Pharmacology, 2022
Zita Wachal, Anna Szilágyi, Barbara Takács, Adrienn Mónika Szabó, Dániel Priksz, Mariann Bombicz, Judit Szilvássy, Béla Juhász, Zoltán Szilvássy, Balázs Varga   +9 more
doaj   +1 more source

Energy viewer: user evaluation and results

, 2008
Deliverable: Report for the ERG ...
Hansen, Preben,
core  

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Diagnostic Significance of Immunohistochemical Expression of E-26 Transformation-Specific (ETS)-Related Gene (ERG) and Golgi Membrane Protein 1 (GOLM1) in Prostatic Carcinoma

Journal of Urological Surgery
Objective: Diagnosis of prostatic adenocarcinoma (PAC) and differentiation from benign mimickers’ lesions represent one of the most challenging problems.
Safaa Abdallah Ahmed, Masoud M. Omar, Hanaa A. Atwa, Mohamed Abdelaleem, Aziza E. Abdelrahman   +4 more
doaj   +1 more source

Clinical manifestations of dual‐gene variants in retinitis pigmentosa

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinitis pigmentosa (RP) is an inherited retinal disease (IRD), whereby each affected individual typically harbours pathogenic variants in a single causative gene, yet the disorder exhibits marked genetic heterogeneity, with more than 100 genes reported to underlie RP.
Lasse Wolfram, Jan‐Philipp Bodenbender, David A. Merle, Milda Reith, Anton Sonntag, Krunoslav Stingl, Tobias B. Haack, Theresia Zuleger, Bernd Wissinger, Laura Kühlewein, Katarina Stingl, Susanne Kohl   +11 more
wiley   +1 more source