Results 211 to 220 of about 6,538 (228)

Survival of the unfittest: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitness.

Hans Carolus, Vladislav Biriukov, Jolien Vreys, Celia Lobo Romero, J Herrera, Rudy Vergauwen, Dimitrios Sofras, Giel Vanreppelen, Lore Vinken, Basil Britto Xavier, Toni Gabaldón, Katrien Lagrou, Reinout Naesens, Patrick Van Dijck   +13 more
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Insights into the structure, function, and impact of <i>Candida albicans UPC2</i> gene on azole resistance; a mini-review. [PDF]

Curr Med Mycol
Hoseinnejad A, Mahdizade AH, Erfaninejad M, Kermani F, Ghazanfari M, Arbabi A, Bahreiny SS, Bozorgomid A, Moradi M, Haghani I, Abastabar M.   +10 more
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Detection of ERG11 gene in fluconazole resistant urinary candida isolates

Egyptian journal of Immunology, 2022
Candida species resistant to fluconazole and voriconazole were screened for the presence of ERG11gene by polymerase chain reaction (PCR). Also, the association of this gene with the demonstration of Candida virulence factors; biofilm formation, phospholipase and proteinases activities were studied.
Manal, El Said, Hala, Badawi, Doaa, Gamal, Dalia, Salem, Heba, Dahroug, Amira, El-Far   +5 more
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Induced expression of Ganoderma boninense Lanosterol 14α-Demethylase (ERG11) during interaction with oil palm

Molecular Biology Reports, 2022
The basidiomycete fungus, Ganoderma boninense is the main contributor to oil palm Basal Stem Rot (BSR) in Malaysia and Indonesia. Lanosterol 14α-Demethylase (ERG11) is a key enzyme involved in biosynthesis of ergosterol, which is an important component in the fungal cell membrane.
Fook-Hwa Lim, Omar Abd Rasid, Abu Seman Idris, Abdul Wahab Mohd As’wad, Ganesan Vadamalai, Ghulam Kadir Ahmad Parveez, Mui-Yun Wong   +6 more
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ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates

Archives of Microbiology, 2015
Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance.
Yonghao, Xu, Fang, Sheng, Jie, Zhao, Lamei, Chen, Chunyang, Li   +4 more
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Association of T916C (Y257H) mutation inCandida albicans ERG11with fluconazole resistance

Mycoses, 2012
SummaryRepeated and prolonged use of fluconazole in treating candidosis leads to drug resistance. The aim of this study was to confirm the relationship between T916C (Y257H) mutation inCandida albicans ERG11and fluconazole resistance. We replaced one copy ofERG11withERG11containing the T916C mutation inC.
Jie, Zhao, Yonghao, Xu, Chunyang, Li
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ERG11 Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles

Antimicrobial Agents and Chemotherapy, 2022
We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into
João Nobrega de Almeida, Cristina Jimenez-Ortigosa, Elaine Cristina Francisco, Arnaldo L. Colombo, David S. Perlin   +4 more
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Cloning and characterization of the lanosterol 14α-demethylase (ERG11) gene in Cryptococcus neoformans

Biochemical and Biophysical Research Communications, 2004
The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar, J, Fu, M G, Rinaldi, S L, Kelly, D E, Kelly, D C, Lamb, S M, Keller, B L, Wickes   +7 more
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[Analysis of ERG11 gene mutation in Candida albicans].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2007
To study the relationship between fluconazole (FCZ)-resistance of Candida albicans and the mutation of ERG11 gene encoding FCZ-targeted enzyme.Three strains of FCZ-susceptible and 10 FCZ-resistent C. albicans were isolated from the urethra, vagina, oropharynx, respiratory tract, prostate secretion and blood samples.
Ying-bin, Wang, Hong, Wang, Hui-yu, Guo, Yong-zhong, Zhao, Shen-qiu, Luo   +4 more
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The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen, Tan, Jinqing, Zhang, Wei, Chen, Yi, Sun, Zhe, Wan, Ruoyu, Li, Wei, Liu   +6 more
openaire   +2 more sources