Results 111 to 120 of about 1,990 (193)

Species Differences in the Pharmacology of the 5-hydroxytryptamine2 Receptor: Structurally Specific Differentiation by Ergolines and Tryptamines.

Journal of Pharmacology and Experimental Therapeutics, 1993
Species differences in the recognition of a series of ergolines by the 5-hydroxytryptamine2 (5-HT2, serotonin2) receptor were investigated in four species, the rat, pig, squirrel monkey and human.
V L Lucaites, D L Nelson
exaly   +2 more sources

Species Variations in Transmembrane Region V of the 5-Hydroxytryptamine Type 2A Receptor Alter the Structure-Activity Relationship of Certain Ergolines and Tryptamines.

Molecular Pharmacology, 1994
Previous work has suggested that species differences in the structure-activity relationship for ergolines and tryptamines at the 5-hydroxytryptamine (5-HT)2A (formerly known as the 5-HT2) receptor are related to aliphatic substitution at the N1-position ...
Melvyn Báez, M P Johnson, D L Nelson
exaly   +2 more sources

From Ergolines to Indoles: Improved Inhibitors of the Human H3 Receptor for the Treatment of Narcolepsy

ChemMedChem, 2015
Ergolines were recently identified as a novel class of H3-Receptor (H3R) inverse agonist. While their optimization led to drug candidates with encouraging properties for the treatment of narcolepsy, brain penetration remained low. To overcome this issue,
Y. Auberson, T. Troxler, Xue-Chun Zhang, Charles R. Yang, D. Feuerbach, Yu-Chih Liu, B. Lagu, M. Perrone, Lijun Lei, Xiaoxia Shen, Du-Shan Zhang, Chunxiu Wang, Tie-Lin Wang, K. Briner, M. Bock   +14 more
semanticscholar   +2 more sources

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.

Bioorganic & Medicinal Chemistry Letters, 2011
The structure activity relationship of highly potent special ergolines which selectively block the chemokine receptor CXCR3 is reported. The most potent compounds showed IC50 values below 10 nM in both ligand binding and Ca2+-mobilization assays. However,
G. Thoma, Rolf Baenteli, I. Lewis, D. Jones, J. Kovarik, M. Streiff, H. Zerwes   +6 more
semanticscholar   +2 more sources

N(1)-Substituted Ergolines and Tryptamines Show Species Differences for the Agonist-Labeled 5-HT2 Receptor

European Journal of Pharmacology, 1993
David L. Nelson, James E Audia, M P Johnson   +2 more
exaly   +2 more sources

Agonism at 5-HT2B Receptors Is Not a Class Effect of the Ergolines

European Journal of Pharmacology, 2005
Heinz H Pertz
exaly   +2 more sources

Electrophilic Substitution of Lithiated Ergolines

Tetrahedron Letters, 1988
Abstract Substitution of the ergoline derivative terguride 1 in the positions 2, 12 and 13 is effected by reaction of the respective bromo-ergolines with tert .-butyllithium and an electrophile in a regioselective manner.
Gerhard Sauer, Joseph Heindl, Helmut Wachtel   +2 more
exaly   +3 more sources

Octahydrobenzo[g]Quinolines: Potent Dopamine Agonists Which Show the Relationship Between Ergolines and Apomorphine

Journal of Medicinal Chemistry, 1985
Trevor J Petcher, T J Petcher
exaly   +2 more sources

Ergot Alkaloids. Ergolines and Related Compounds as Inhibitors of Prolactin Release

Journal of Medicinal Chemistry, 1974
John M Cassady, J M Cassady, J A Clemens
exaly   +2 more sources

Conversion of Ergolines to Hexahydro- and Octahydrobenzo[f]Quinolines (Depyrroloergolines)

Journal of Medicinal Chemistry, 1980
J A Clemens, Edmund C Kornfeld, N J Bach
exaly   +2 more sources