Results 131 to 140 of about 674 (175)
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A Crystallographic Investigation of Ergolines
Structural Chemistry, 2002The X-ray crystal structures of three ergoline derivatives have been completed and are reported herein. These include mesulergine hydrochloride (III), pergolide methanesulfonate (IV), and dihydroergocriptine hydrate (V). These molecules show dopamine agonist activity at the D2 receptor.
Naijue Zhu +3 more
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Tetrahedron, 1965
Abstract The NH region of the IR spectra of lysergamides and dihydrolysergamides are reported, discussed and the bands assigned. Axial and equatorial amides are clearly distinguishable, the former present between the amide hydrogen and the tertiary nitrogen atom an intramolecular hydrogen bond which can very in strength.
L. Bernardi, W. Barbieri
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Abstract The NH region of the IR spectra of lysergamides and dihydrolysergamides are reported, discussed and the bands assigned. Axial and equatorial amides are clearly distinguishable, the former present between the amide hydrogen and the tertiary nitrogen atom an intramolecular hydrogen bond which can very in strength.
L. Bernardi, W. Barbieri
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Ergoline derivatives: receptor affinity and selectivity
Il Farmaco, 1999Ergot comprises a group of indole alkaloids which are predominantly found in various species of the ascomycete Claviceps. In pharmacopoeias, the sclerotia of Claviceps purpurea (Fr.) Tulasne parasitizing on rye, Secale cereale L., are designed as ergot or Secale cornutum.
S, Mantegani, E, Brambilla, M, Varasi
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Nidation Inhibition by Simple Ergoline Derivatives
Journal of Pharmaceutical Sciences, 1975The ability of four ergoline-type compounds (elymoclavine, its O-benzoate and O-carbamate, and N-methyl-6,7-secoelymoclavine) to inhibit nidation in rats was determined and found to parallel their prolactin-inhibiting activity.
K, Rezábek, J M, Cassady, H G, Floss
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Ergoline Alkaloids in Tropical Wood Roses
Science, 1965Extracts of Argyreia nervosa , a tropical wood rose, contain appreciable quantities of ergoline alkaloids tentatively identified as ergine isoergine, and penniclavine together with related substances.
J W, Hylin, D P, Watson
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Agonism at 5-HT2B receptors is not a class effect of the ergolines
European Journal of Pharmacology, 2005Restrictive cardiac valvulopathies observed in Parkinson patients treated with the ergoline dopamine agonist pergolide have recently been associated with the agonist efficacy of the drug at 5-hydroxytryptamine2B (5-HT2B) receptors. To evaluate whether agonism at 5-HT2B receptors is a phenomenon of the class of the ergolines, we studied 5-HT2B receptor ...
Heinz H Pertz
exaly +3 more sources
1,2-Fused derivatives of ergoline
Collection of Czechoslovak Chemical Communications, 19822-Formylergoline derivatives I and II were condensed with methyl isonitrilacetate in the presence of a base. Depending on the nature of this base, the main products of the reaction were either derivatives of pyrimido[1,6-a]ergoline, III and IV, or derivatives of 2-formylamino-3-oxo-3H-pyrrolo[1,2-a]ergoline, V and VI.
Jan Beneš, Jiří Holubek
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2-Acylated derivatives of ergoline
Collection of Czechoslovak Chemical Communications, 1982Reactions of ergoline derivatives Ia-VIIa with anhydrides of low-molecular-weight aliphatic acids, catalysed by boron trifluoride etherate, gave 2-acylated derivatives Ib-Id, IIb-IId, IIIb-Vb, or 1,2-diacylated derivatives VIb and VIIb. The compound IIb exhibited a hypotensive effect.
Jan Beneš, Jiří Křepelka
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Antihypertensive ergoline derivatives.
Drug design and delivery, 1989Novel ergolines were synthesized and screened in spontaneous hypertensive rats (SHR) with the aim of finding a new class of ergot related antihypertensives. Their prolactin inhibitory effect (measured as nidation inhibition in rats), acute toxicity (LD50) and interference with CNS function (Irwin test) were also evaluated as a measure of selectivity ...
S, Mantegani +6 more
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2012
The photoaddition of water to the ergot clavinet alkaloid, lysergene, has been reported by Shough and Taylor. The product of this reaction, 10-hydroxyagroclabine, was found to rearrange in aqueous acid to give the 8-hydroxy derivative setoclavine. A second photoaddition of water than gave the 8,10-dihydroxy derivative, lumisetoclavine.
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The photoaddition of water to the ergot clavinet alkaloid, lysergene, has been reported by Shough and Taylor. The product of this reaction, 10-hydroxyagroclabine, was found to rearrange in aqueous acid to give the 8-hydroxy derivative setoclavine. A second photoaddition of water than gave the 8,10-dihydroxy derivative, lumisetoclavine.
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