Results 121 to 130 of about 674 (175)
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Ergoline and non-ergoline derivatives in the treatment of Parkinson’s disease
Journal of Neurology, 2006There are a large variety of dopamine agonists available. Especially de novo patients are treated with dopamine agonists to avoid dyskinesia. Dopamine agonists can be subdivided into ergoline and non-ergoline derivatives. This distinction raises the question whether there are differences in the effects to treat symptoms, not only in the side effects ...
Heinz, Reichmann +6 more
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Stimulation of pre- and postsynaptic dopamine receptors by an ergoline and by a partial ergoline
Brain Research, 1981The capacity of the ergoline, pergolide, and of the partial ergoline, LY 141865, to stimulate pre- and postsynaptic dopamine (DA) receptors was investigated. Binding studies have revealed that pergolide has a high affinity, while the partial ergoline, LY 141865, has a low affinity for the postsynaptic striatal DA receptors in vitro.
J M, Rabey +4 more
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Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines)
Journal of Medicinal Chemistry, 1980 Nicholas J Bach, J A Clemens
exaly +2 more sources
Serotonergic ergoline derivatives
Bioorganic & Medicinal Chemistry Letters, 1998Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT1A or 5-HT2 affinity and ...
S, Mantegani +6 more
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Preparation and Characterization of Ergoline Thiazolidinones and an Ergoline Imidazolidinone
Archiv der Pharmazie, 1986AbstractThe preparation of the ergoline thiazolidinones 2,3 and the ergoline imidazolidinone 5 is described. The 13C‐ and 15N‐NMR spectra of the 15N‐labelled compounds 15N‐ 2a and 15N‐3a allow the distinction of the two isomers.
Karlheinz Seifert +2 more
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Ergolines as selective 5-HT1 agonists
Journal of Medicinal Chemistry, 1988The synthesis and serotonin receptor subtype affinity of a series of ergolines are described. High selectivity for the 5-HT1 subtype was found with a number of 8-substituted (3 beta, 5 beta)-9,10-didehydro-6-methylergolines. The more potent and selective of these compounds increased the concentration of serotonin and decreased the concentration of 5 ...
John S Ward +2 more
exaly +3 more sources
Chemischer Informationsdienst, 1986
AbstractErgolin‐thioharnstoffe (I) reagieren mit Acetylendicarbonsäureestern (II) zum Isomerengemisch der Ergolin‐thiazolidinone (III) und (IV).
K. SEIFERT, S. + HAERTLING, S. JOHNE
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AbstractErgolin‐thioharnstoffe (I) reagieren mit Acetylendicarbonsäureestern (II) zum Isomerengemisch der Ergolin‐thiazolidinone (III) und (IV).
K. SEIFERT, S. + HAERTLING, S. JOHNE
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Inhibition of Prolactin Secretion by Ergolines
Endocrinology, 1974Peptide-containing ergot alkaloids and synthetic ergoline derivatives were administered to reserpine-treated male rats in order to evaluate their prolactin-inhibiting properties. Each compound was administered ip at a standard 50 ¼g/kg dose. The 9,10-dihydrogenated ergots, dihydroergocornine, and dihydroergocryptine were able to inhibit prolactin to ...
J A, Clemens +4 more
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Electrochemical Oxidation of Ergolines
Helvetica Chimica Acta, 1992AbstractAn electrochemical procedure for the preparation of D‐3‐alkoxy‐halogen‐2,3‐dihydro‐6‐methyl‐2‐oxoergolines‐I is described.
Karlheinz Seifert +2 more
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