Results 141 to 150 of about 674 (175)

ChemInform Abstract: Serotonergic Ergoline Derivatives.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. MANTEGANI, E. BRAMBILLA, C. CACCIA, G. DAMIANI, M. G. FORNARETTO, R. A. MCARTHUR, M. VARASI   +6 more
openaire   +1 more source

Neurochemical Effects of Ergoline Derivatives

1986
Sermion (nicergoline) is an ergoline derivative clinically active in chronic cerebral vascular insufficiency [1] and in patients with senile dementia [2].
A. Moretti, N. Carfagna, C. Caccia, M. Carpentieri, A. Amico, G. Marchi, F. Trunzo, null Trunzo   +7 more
openaire   +1 more source

Synthetic entry into N(5)-ergolines

Journal of the Chemical Society, Chemical Communications, 1985
The first synthesis of the N(5)-ergoline system has achieved via a hetero Diels–Alder reaction on readily accessible substituted phenyl butadiene.
Jack E. Baldwin, Andrew K. Forrest, Sam Monaco, Robert J. Young   +3 more
openaire   +1 more source

Ergoline congeners as potential inhibitors of prolactin release 2

Journal of Medicinal Chemistry, 1976
In our attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure, we have prepared one indolealkylamine and several 2-aminotetralin derivatives. These congeners have been evaluated for inhibition of prolactin release in vivo.
D B, Rusterholz, C F, Barfknecht, J A, Clemens   +2 more
openaire   +2 more sources

Radioimmunoassay for the Synthetic Ergoline Derivative Cabergoline in Biological Fluids

Journal of Immunoassay, 1992
An antiserum against cabergoline, a powerful dopamine-agonist under clinical trials for the treatment of Parkinson's disease and hyperprolactinemia, has been raised in rabbits by immunization with an immunogen produced by conjugation of cabergoline to bovine serum albumin. The antiserum was able to bind a derivative of cabergoline labelled with tritium
S, Persiani, E, Pianezzola, F, Broutin, G, Fonte, M, Strolin Benedetti   +4 more
openaire   +2 more sources

Initial treatment of parkinsonism with 8‐alpha‐amino‐ergoline

Neurology, 1985
We treated 12 patients with Parkinson's disease with an 8-alpha-amino-ergoline derivative, CU 32-085. The daily dosage was increased slowly to 7 mg over 9 weeks, held constant for 8 weeks, then replaced by placebo for 4 weeks. We found statistically significant benefit over placebo or pretreatment disability.
H, Teräväinen, J, Huttunen, M, Hietanen   +2 more
openaire   +2 more sources

Sequential Aminodiene Diels−Alder Approach to the Ergoline Skeleton

The Journal of Organic Chemistry, 2005
Through a novel sequence of aminodiene Diels-Alder reactions, several substituted amidofurans were readily converted to tricyclic ketones in good yield. The formation of the tricyclic ketone system is the result of a ring opening and dehydration of a transient oxabicyclic adduct formed by an intramolecular Diels-Alder cycloaddition of an amidofuran ...
Albert, Padwa, Scott K, Bur, Hongjun, Zhang   +2 more
openaire   +2 more sources

Synthesis and in vitro and in vivo evaluation of dopaminergic ergoline derivatives

Il Farmaco, 1998
A series of ergoline-amides was synthesised in the discovery of new dopaminomimetic agents. Several compounds exhibited in vivo high prolactin lowering activity (indirectly measured by the nidation test) in rats. For the most active, the potential anti-Parkinson activity was evaluated by observation of the contralateral turning behaviour in 6-OH-DA ...
S, Mantegani, E, Brambilla, C, Caccia, E, Di Salle, M A, Cervini, R A, McArthur, G, Traquandi, M, Varasi   +7 more
openaire   +2 more sources

[Ergoline-induced retroperitoneal fibrosis].

Ugeskrift for laeger, 2006
A 69-year-old man presented with anaemia, swelling of the legs and scrotum, weight gain and fatigue. MR scan and laboratory findings initiated a search for cancer, but eventually retroperitoneal fibrosis (RF) was suspected. A medical review revealed that an ergoline-based drug known to be associated with RF had been used for eight years.
Lars, Munksgaard, Hanne, Madsen, Pia Birgitte R, Svolgaard, Jens Møller, Rasmussen   +3 more
openaire   +1 more source

Antiulcer and antisecretory ergoline derivatives.

Farmaco (Societa chimica italiana : 1989), 1989
New ergoline derivatives exhibiting antiulcer and antisecretory activities were synthesized and tested. Stereochemical modification of the ergoline skeleton was found to influence the selective activity of the compounds.
D, Ruggieri, C, Arrigoni, E, Di Salle, A, Temperilli, D, Giudici   +4 more
openaire   +1 more source