Results 141 to 150 of about 1,990 (193)

Synthesis of ergoline ethers

2012
The photoaddition of water to the ergot clavinet alkaloid, lysergene, has been reported by Shough and Taylor. The product of this reaction, 10-hydroxyagroclabine, was found to rearrange in aqueous acid to give the 8-hydroxy derivative setoclavine. A second photoaddition of water than gave the 8,10-dihydroxy derivative, lumisetoclavine.
openaire   +1 more source

Antihypertensive ergoline derivatives.

Drug design and delivery, 1989
Novel ergolines were synthesized and screened in spontaneous hypertensive rats (SHR) with the aim of finding a new class of ergot related antihypertensives. Their prolactin inhibitory effect (measured as nidation inhibition in rats), acute toxicity (LD50) and interference with CNS function (Irwin test) were also evaluated as a measure of selectivity ...
S, Mantegani, A, Temperilli, G, Traquandi, P, Salvati, E, Di Salle, E, Lamberti, A, Bonsignori   +6 more
openaire   +1 more source

Critical interaction of the dopamine D1 receptor with ergolines: the roles of conserved aromatic residues in transmembrane six segment (656.5)

, 2014
Sangmin Lee, R. Mailman
semanticscholar   +1 more source

Pharmacological properties of a wide array of ergolines at functional alpha1-adrenoceptor subtypes

Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
T. Görnemann, S. Jähnichen, B. Schurad, K. Latté, R. Horowski, J. Tack, M. Flieger, H. Pertz   +7 more
semanticscholar   +1 more source

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Bioorganic & Medicinal Chemistry Letters, 2009
G. Thoma, Rolf Baenteli, I. Lewis, T. Wagner, L. Oberer, W. Blum, F. Glickman, M. Streiff, H. Zerwes   +8 more
semanticscholar   +1 more source

Inhibition of prolactin by ergoline congeners

Journal of Medicinal Chemistry, 1974
Charles F. Barfknecht, David B. Rusterholz, Jonathan A. Parsons   +2 more
openaire   +2 more sources

Cycloalkanecarboxylic esters derived from lysergol, dihydrolysergol-I, and elymoclavine as partial agonists and antagonists at rat 5-HT2A receptors: pharmacological evidence that the indolo[4,3-fg]quinoline system of the ergolines is responsible for high 5-HT2A receptor affinity.

Journal of Medicinal Chemistry, 1999
Heinz H. Pertz, H.-Christian Milhahn, E. Eich   +2 more
semanticscholar   +1 more source

Ergoline analogues

2022
MURATORE MASSIMO, MOGHADDAM AMIR LOTFI, WONG CHRISTOPHER   +2 more
openaire   +4 more sources

On the Stereochemistry of Dopaminergic Ergoline Derivatives

Molecular Pharmacology, 1981
N, Camerman, A, Camerman
openaire   +2 more sources

In vitro antiplasmodial activities of semisynthetic N,N'-spacer-linked oligomeric ergolines.

Bioorganic & Medicinal Chemistry, 2004
K. Jenett‐Siems, I. Köhler, Carola Kraft, H. Pertz, V. Křen, A. Fis̆erová, M. Kuzma, J. Ulrichová, U. Bienzle, E. Eich   +9 more
semanticscholar   +1 more source