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Inhibition of Prolactin Secretion by Ergolines
Endocrinology, 1974Peptide-containing ergot alkaloids and synthetic ergoline derivatives were administered to reserpine-treated male rats in order to evaluate their prolactin-inhibiting properties. Each compound was administered ip at a standard 50 ¼g/kg dose. The 9,10-dihydrogenated ergots, dihydroergocornine, and dihydroergocryptine were able to inhibit prolactin to ...
J A, Clemens +4 more
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Regiocontrolled electrochemical cyanation of ergolines
Tetrahedron Letters, 1983Abstract An electrochemical procedure for the preparation of the 2-cyano ergolines (2) is described.
Karlheinz Seifert +2 more
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Electrophilic substitution of lithiated ergolines
Tetrahedron Letters, 1988Abstract Substitution of the ergoline derivative terguride 1 in the positions 2, 12 and 13 is effected by reaction of the respective bromo-ergolines with tert .-butyllithium and an electrophile in a regioselective manner.
Gerhard Sauer +2 more
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Two novel prolactin release-inhibiting 8α-amino-ergolines
Experientia, 1979Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.
E, Flückiger +5 more
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Preparation and Characterization of Ergoline Thiazolidinones and an Ergoline Imidazolidinone
Archiv der Pharmazie, 1986AbstractThe preparation of the ergoline thiazolidinones 2,3 and the ergoline imidazolidinone 5 is described. The 13C‐ and 15N‐NMR spectra of the 15N‐labelled compounds 15N‐ 2a and 15N‐3a allow the distinction of the two isomers.
Karlheinz Seifert +2 more
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Ergoline and non-ergoline derivatives in the treatment of Parkinson’s disease
Journal of Neurology, 2006There are a large variety of dopamine agonists available. Especially de novo patients are treated with dopamine agonists to avoid dyskinesia. Dopamine agonists can be subdivided into ergoline and non-ergoline derivatives. This distinction raises the question whether there are differences in the effects to treat symptoms, not only in the side effects ...
Heinz, Reichmann +6 more
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Electrochemical Oxidation of Ergolines
Helvetica Chimica Acta, 1992AbstractAn electrochemical procedure for the preparation of D‐3‐alkoxy‐halogen‐2,3‐dihydro‐6‐methyl‐2‐oxoergolines‐I is described.
Karlheinz Seifert +2 more
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Tetrahedron, 1965
Abstract The NH region of the IR spectra of lysergamides and dihydrolysergamides are reported, discussed and the bands assigned. Axial and equatorial amides are clearly distinguishable, the former present between the amide hydrogen and the tertiary nitrogen atom an intramolecular hydrogen bond which can very in strength.
L. Bernardi, W. Barbieri
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Abstract The NH region of the IR spectra of lysergamides and dihydrolysergamides are reported, discussed and the bands assigned. Axial and equatorial amides are clearly distinguishable, the former present between the amide hydrogen and the tertiary nitrogen atom an intramolecular hydrogen bond which can very in strength.
L. Bernardi, W. Barbieri
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Ergoline derivatives: receptor affinity and selectivity
Il Farmaco, 1999Ergot comprises a group of indole alkaloids which are predominantly found in various species of the ascomycete Claviceps. In pharmacopoeias, the sclerotia of Claviceps purpurea (Fr.) Tulasne parasitizing on rye, Secale cereale L., are designed as ergot or Secale cornutum.
S, Mantegani, E, Brambilla, M, Varasi
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