Results 161 to 170 of about 1,343 (193)

Synthetic entry into N(5)-ergolines

Journal of the Chemical Society, Chemical Communications, 1985
AbstractButadien (I) wird in das Butadienylbenzol (IV) übergeführt, das die Addukte (VI) und (VIII) bildet.
Jack E. Baldwin, Andrew K. Forrest, Robert J. Young, Sam Monaco   +3 more
openaire   +3 more sources

Neurochemical Effects of Ergoline Derivatives

1986
Sermion (nicergoline) is an ergoline derivative clinically active in chronic cerebral vascular insufficiency [1] and in patients with senile dementia [2].
Trunzo, G. Marchi, C. Caccia, A. Amico, A. Moretti, M. Carpentieri, F. Trunzo, N. Carfagna   +7 more
openaire   +2 more sources

ChemInform Abstract: Conformationally Blocked Ergoline Derivatives.

ChemInform, 1988
AbstractErgoline compounds are capable of binding to adrenergic, dopaminergic and serotoninergic receptors.
V. Malatesta, M. Ballabio, D. Ruggieri, A. Temperilli   +3 more
openaire   +2 more sources

Sequential Aminodiene Diels−Alder Approach to the Ergoline Skeleton

The Journal of Organic Chemistry, 2005
Through a novel sequence of aminodiene Diels-Alder reactions, several substituted amidofurans were readily converted to tricyclic ketones in good yield. The formation of the tricyclic ketone system is the result of a ring opening and dehydration of a transient oxabicyclic adduct formed by an intramolecular Diels-Alder cycloaddition of an amidofuran ...
Albert Padwa, Scott K. Bur, Hongjun Zhang   +2 more
openaire   +3 more sources

Dopaminergic activity of some simplified ergoline derivatives

Drug Development Research, 1981
AbstractThe dopamine (DA) agonist activity of new simplified ergoline derivatives (RU 27849, RU 28251, and RU 28306) was studied in comparison with bromocriptine. In contrast to bromocriptine, the three compounds were weak displacers of 3H‐dihydroergocriptine or 3H‐spiroperidol binding from bovine anterior pituitary or rat striatal membrane sites and ...
Catherine Euvrard, Fernand Labrie, Michel Fortin, Claude Oberlander, Louise Ferland, Jacques R. Boissier   +5 more
openaire   +2 more sources

Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding.

Molecular Pharmacology, 1995
In this paper we show that a highly conserved aromatic residue, phenylalanine at the 340-position, is essential for ergoline binding to 5-hydroxytryptamine2A receptors. We hypothesized that F340 was essential for a specific aromatic-aromatic interaction (e.g., pi-pi or hydrophobic) between the phenyl moiety of F340 and the aromatic ring of the ergoline
M S, Choudhary, N, Sachs, A, Uluer, R A, Glennon, R B, Westkaemper, B L, Roth   +5 more
openaire   +2 more sources

Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines)

Journal of Medicinal Chemistry, 1980
AbstractErgonovin (Ia), Agroclavin (Ib) und Pergolidmesylat (Ic) werden zu den Ketoformamiden (II) gespalten, die über die Aminoketone (III) in die Ketone (IV) umgewandelt werden.
Bach Nicholas J, Kornfeld Edmund C, James A. Clemens, E. B. Smalstig   +3 more
openaire   +4 more sources

In vivo and in vitro dopaminergic effects of three ergoline fragments

Naunyn-Schmiedeberg's Archives of Pharmacology, 1984
The pharmacological effects of three ergoline fragments (BD-179, BD-271 and BD-214) were studied in vivo using the cat cardioaccelerator nerve preparation and in vitro using field stimulated isolated cat right atria. BD-179 and BD-271 produced dose dependent inhibition of tachycardia due to electrical stimulation of the right postganglionic ...
John P. Long, Jay C. Koons, Joseph G. Cannon   +2 more
openaire   +3 more sources

Agonism at 5-HT2B receptors is not a class effect of the ergolines

European Journal of Pharmacology, 2005
Restrictive cardiac valvulopathies observed in Parkinson patients treated with the ergoline dopamine agonist pergolide have recently been associated with the agonist efficacy of the drug at 5-hydroxytryptamine2B (5-HT2B) receptors. To evaluate whether agonism at 5-HT2B receptors is a phenomenon of the class of the ergolines, we studied 5-HT2B receptor ...
Sven Jähnichen, Heinz H. Pertz, Reinhard Horowski   +2 more
openaire   +3 more sources

Initial treatment of parkinsonism with 8‐alpha‐amino‐ergoline

Neurology, 1985
We treated 12 patients with Parkinson's disease with an 8-alpha-amino-ergoline derivative, CU 32-085. The daily dosage was increased slowly to 7 mg over 9 weeks, held constant for 8 weeks, then replaced by placebo for 4 weeks. We found statistically significant benefit over placebo or pretreatment disability.
Juha Huttunen, Heikki Teräväinen, Marja Hietanen   +2 more
openaire   +3 more sources