Results 161 to 170 of about 1,329 (197)

On the alleged electrochemical methoxylation of ergolines

Tetrahedron Letters, 1983
Abstract The products obtained by controlled potential electrolysis of ergolines (1) in 0.5N KOH-MeOH previously described as 2-methoxy derivatives (2) are actually the 1-hydroxy methyl ergolines (3).
B. Danieli, G. Fiori, G. Lesma, G. Palmisano   +3 more
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2-Acylated derivatives of ergoline

Collection of Czechoslovak Chemical Communications, 1982
Reactions of ergoline derivatives Ia-VIIa with anhydrides of low-molecular-weight aliphatic acids, catalysed by boron trifluoride etherate, gave 2-acylated derivatives Ib-Id, IIb-IId, IIIb-Vb, or 1,2-diacylated derivatives VIb and VIIb. The compound IIb exhibited a hypotensive effect.
Jiří Křepelka, Jan Beneš
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1,2-Fused derivatives of ergoline

Collection of Czechoslovak Chemical Communications, 1982
2-Formylergoline derivatives I and II were condensed with methyl isonitrilacetate in the presence of a base. Depending on the nature of this base, the main products of the reaction were either derivatives of pyrimido[1,6-a]ergoline, III and IV, or derivatives of 2-formylamino-3-oxo-3H-pyrrolo[1,2-a]ergoline, V and VI.
Jan Beneš, Jiří Holubek
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Neurochemical Effects of Ergoline Derivatives

1986
Sermion (nicergoline) is an ergoline derivative clinically active in chronic cerebral vascular insufficiency [1] and in patients with senile dementia [2].
Trunzo, G. Marchi, C. Caccia, A. Amico, A. Moretti, M. Carpentieri, F. Trunzo, N. Carfagna   +7 more
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Synthetic entry into N(5)-ergolines

Journal of the Chemical Society, Chemical Communications, 1985
AbstractButadien (I) wird in das Butadienylbenzol (IV) übergeführt, das die Addukte (VI) und (VIII) bildet.
Jack E. Baldwin, Andrew K. Forrest, Robert J. Young, Sam Monaco   +3 more
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ChemInform Abstract: Conformationally Blocked Ergoline Derivatives.

ChemInform, 1988
AbstractErgoline compounds are capable of binding to adrenergic, dopaminergic and serotoninergic receptors.
V. Malatesta, M. Ballabio, D. Ruggieri, A. Temperilli   +3 more
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Sequential Aminodiene Diels−Alder Approach to the Ergoline Skeleton

The Journal of Organic Chemistry, 2005
Through a novel sequence of aminodiene Diels-Alder reactions, several substituted amidofurans were readily converted to tricyclic ketones in good yield. The formation of the tricyclic ketone system is the result of a ring opening and dehydration of a transient oxabicyclic adduct formed by an intramolecular Diels-Alder cycloaddition of an amidofuran ...
Albert Padwa, Scott K. Bur, Hongjun Zhang   +2 more
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Dopaminergic activity of some simplified ergoline derivatives

Drug Development Research, 1981
AbstractThe dopamine (DA) agonist activity of new simplified ergoline derivatives (RU 27849, RU 28251, and RU 28306) was studied in comparison with bromocriptine. In contrast to bromocriptine, the three compounds were weak displacers of 3H‐dihydroergocriptine or 3H‐spiroperidol binding from bovine anterior pituitary or rat striatal membrane sites and ...
Catherine Euvrard, Fernand Labrie, Michel Fortin, Claude Oberlander, Louise Ferland, Jacques R. Boissier   +5 more
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Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding.

Molecular Pharmacology, 1995
In this paper we show that a highly conserved aromatic residue, phenylalanine at the 340-position, is essential for ergoline binding to 5-hydroxytryptamine2A receptors. We hypothesized that F340 was essential for a specific aromatic-aromatic interaction (e.g., pi-pi or hydrophobic) between the phenyl moiety of F340 and the aromatic ring of the ergoline
M S, Choudhary, N, Sachs, A, Uluer, R A, Glennon, R B, Westkaemper, B L, Roth   +5 more
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In vivo and in vitro dopaminergic effects of three ergoline fragments

Naunyn-Schmiedeberg's Archives of Pharmacology, 1984
The pharmacological effects of three ergoline fragments (BD-179, BD-271 and BD-214) were studied in vivo using the cat cardioaccelerator nerve preparation and in vitro using field stimulated isolated cat right atria. BD-179 and BD-271 produced dose dependent inhibition of tachycardia due to electrical stimulation of the right postganglionic ...
John P. Long, Jay C. Koons, Joseph G. Cannon   +2 more
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