Results 171 to 180 of about 2,476 (230)

Novel Ergolines as 5‑HT2A Agonists for Treating Mood Disorders.

ACS Medicinal Chemistry Letters
Provided herein are novel ergolines as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating mood disorders, and processes for preparing such compounds.
R. W. Sabnis
semanticscholar   +1 more source

ChemInform Abstract: Preparation and Characterization of Ergoline Thiazolidinones and an Ergoline Imidazolidinone.

Chemischer Informationsdienst, 1986
AbstractErgolin‐thioharnstoffe (I) reagieren mit Acetylendicarbonsäureestern (II) zum Isomerengemisch der Ergolin‐thiazolidinone (III) und (IV).
K. SEIFERT, S. + HAERTLING, S. JOHNE
openaire   +1 more source

Nidation Inhibition by Simple Ergoline Derivatives

Journal of Pharmaceutical Sciences, 1975
The ability of four ergoline-type compounds (elymoclavine, its O-benzoate and O-carbamate, and N-methyl-6,7-secoelymoclavine) to inhibit nidation in rats was determined and found to parallel their prolactin-inhibiting activity.
K, Rezábek, J M, Cassady, H G, Floss
openaire   +2 more sources

Stimulation of pre- and postsynaptic dopamine receptors by an ergoline and by a partial ergoline

Brain Research, 1981
The capacity of the ergoline, pergolide, and of the partial ergoline, LY 141865, to stimulate pre- and postsynaptic dopamine (DA) receptors was investigated. Binding studies have revealed that pergolide has a high affinity, while the partial ergoline, LY 141865, has a low affinity for the postsynaptic striatal DA receptors in vitro.
J M, Rabey, P, Passeltiner, K, Markey, T, Asano, M, Goldstein   +4 more
openaire   +2 more sources

Ergoline Alkaloids in Tropical Wood Roses

Science, 1965
Extracts of Argyreia nervosa , a tropical wood rose, contain appreciable quantities of ergoline alkaloids tentatively identified as ergine isoergine, and penniclavine together with related substances.
J W, Hylin, D P, Watson
openaire   +2 more sources

ChemInform Abstract: Serotonergic Ergoline Derivatives.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. MANTEGANI, E. BRAMBILLA, C. CACCIA, G. DAMIANI, M. G. FORNARETTO, R. A. MCARTHUR, M. VARASI   +6 more
openaire   +1 more source

1,2-Fused derivatives of ergoline

Collection of Czechoslovak Chemical Communications, 1982
2-Formylergoline derivatives I and II were condensed with methyl isonitrilacetate in the presence of a base. Depending on the nature of this base, the main products of the reaction were either derivatives of pyrimido[1,6-a]ergoline, III and IV, or derivatives of 2-formylamino-3-oxo-3H-pyrrolo[1,2-a]ergoline, V and VI.
Jan Beneš, Jiří Holubek
openaire   +1 more source

Antihypertensive ergoline derivatives.

Drug design and delivery, 1989
Novel ergolines were synthesized and screened in spontaneous hypertensive rats (SHR) with the aim of finding a new class of ergot related antihypertensives. Their prolactin inhibitory effect (measured as nidation inhibition in rats), acute toxicity (LD50) and interference with CNS function (Irwin test) were also evaluated as a measure of selectivity ...
S, Mantegani, A, Temperilli, G, Traquandi, P, Salvati, E, Di Salle, E, Lamberti, A, Bonsignori   +6 more
openaire   +1 more source

A Crystallographic Investigation of Ergolines

Structural Chemistry, 2002
The X-ray crystal structures of three ergoline derivatives have been completed and are reported herein. These include mesulergine hydrochloride (III), pergolide methanesulfonate (IV), and dihydroergocriptine hydrate (V). These molecules show dopamine agonist activity at the D2 receptor.
Naijue Zhu, L'Aurelle Johnson, Julian White, Cheryl L. Klein-Stevens   +3 more
openaire   +1 more source

2-Acylated derivatives of ergoline

Collection of Czechoslovak Chemical Communications, 1982
Reactions of ergoline derivatives Ia-VIIa with anhydrides of low-molecular-weight aliphatic acids, catalysed by boron trifluoride etherate, gave 2-acylated derivatives Ib-Id, IIb-IId, IIIb-Vb, or 1,2-diacylated derivatives VIb and VIIb. The compound IIb exhibited a hypotensive effect.
Jan Beneš, Jiří Křepelka
openaire   +1 more source