Results 171 to 180 of about 1,329 (197)
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Agonism at 5-HT2B receptors is not a class effect of the ergolines
European Journal of Pharmacology, 2005Restrictive cardiac valvulopathies observed in Parkinson patients treated with the ergoline dopamine agonist pergolide have recently been associated with the agonist efficacy of the drug at 5-hydroxytryptamine2B (5-HT2B) receptors. To evaluate whether agonism at 5-HT2B receptors is a phenomenon of the class of the ergolines, we studied 5-HT2B receptor ...
Sven Jähnichen +2 more
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Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines)
Journal of Medicinal Chemistry, 1980AbstractErgonovin (Ia), Agroclavin (Ib) und Pergolidmesylat (Ic) werden zu den Ketoformamiden (II) gespalten, die über die Aminoketone (III) in die Ketone (IV) umgewandelt werden.
Bach Nicholas J +3 more
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Radioimmunoassay for the Synthetic Ergoline Derivative Cabergoline in Biological Fluids
Journal of Immunoassay, 1992An antiserum against cabergoline, a powerful dopamine-agonist under clinical trials for the treatment of Parkinson's disease and hyperprolactinemia, has been raised in rabbits by immunization with an immunogen produced by conjugation of cabergoline to bovine serum albumin. The antiserum was able to bind a derivative of cabergoline labelled with tritium
M. Strolin Benedetti +4 more
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Initial treatment of parkinsonism with 8‐alpha‐amino‐ergoline
Neurology, 1985We treated 12 patients with Parkinson's disease with an 8-alpha-amino-ergoline derivative, CU 32-085. The daily dosage was increased slowly to 7 mg over 9 weeks, held constant for 8 weeks, then replaced by placebo for 4 weeks. We found statistically significant benefit over placebo or pretreatment disability.
Juha Huttunen +2 more
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Ergoline congeners as potential inhibitors of prolactin release 2
Journal of Medicinal Chemistry, 1976AbstractIndol (Ia) wird mit Oxalylchlorid zu (Ib) substituiert und nach Überführung in das Amid (II) zum Amin (IIIa) reduziert.
Charles F. Barfknecht +2 more
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Diastereoselectivity in ergoline synthesis: A face selective epoxidation
Tetrahedron Letters, 1989Abstract Epoxidation of 1-Benzoyl-1,2,2a,3-tetrahydrobenz[ cd ]indole ( 4a ) proceeded smoothly with metachloroperbenzoic acid with high exo diastereoselectivity (de = 96%) and chemical yield (97%). The basis for this selectivity was probed with substituent effects, and was extended to other oxidation media.
Marvin Robert Leanna +3 more
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ChemInform Abstract: Synthesis of Chiral Indolizines as Bicyclic Ergoline Analogues.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Bromination of ergolene and ergoline structures — New results
1995Summary The technical aspect of 2-bromo-α-ergocryptine synthesis, including the characterisation and significance of the impurities obtained in the production process, were reviewed. In the continuation new ergolene and ergoline compounds were synthesized and tested for the pharmacological activity.
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On the Stereochemistry of Dopaminergic Ergoline Derivatives
Molecular Pharmacology, 1981N, Camerman, A, Camerman
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BROMERGURIDE - AN ERGOLINE DERIVATIVE WITH ATYPICAL NEUROLEPTIC PROPERTIES
Clinical Neuropharmacology, 1992Reinhard Horowski +2 more
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