Results 51 to 60 of about 674 (175)

D-1-Carboxymethyl-8β-carboxy-6-methylergoline and some 1,8-disubstituted ergolines derived from it

, 1982
Reaction of D-8β-carboxy-6-methylergoline (I) with ethyl bromo acetate gave D-1-carboxy-8β-carboxy-6-methylergoline (II), whose dimethyl ester III was reduced with sodium borohydride, either selectively to D-1-(2-hydroxyethyl)-8β-methoxycarbonyl-6 ...
Jan Šmidrkal, Miroslav Semonský
core   +1 more source

Diversity-optimized route to the ergoline skeleton and the efficient synthesis and investigation of new HCV inhibitors

, 2013
Includes bibliographical references (p. 54-56).I. Diversity-Optimized Route to the Ergoline Skeleton The ergot alkaloids possess perhaps the greatest diversity of any class of natural products.
Burley, Scott D.
core  

Arylpiperazine derivatives as serotoninergic ligands

, 2009
Serotonin is a neuromediator well known for its implication in mood regulation, anxiety, depression,insomnia as well as in normal human function such as sleep, sexual activity and appetite and recently it was demonstrated its involvement in the ...
SEVERINO B, MASSARELLI, PAOLA, SANTAGADA V, FIORINO F, FRECENTESE F, RENNER C, CALIENDO G., DE ANGELIS F, ESPOSITO A, PERISSUTTI E   +9 more
core  

Receptor-Based Pharmacophores for Serotonin 5-HT₇R AntagonistsImplications to Selectivity

, 2016
A set of 31 diversified 5-HT7 receptor antagonists was automatically docked to a conformational ensemble of rhodopsin-based 5-HT7R models (flexible docking). It was found that ergolines, aporphines, and tricyclic psychotropic agents were always docked in
Andrzej J. Bojarski (499184), Marcin Kołaczkowski (805225), Maciej Pawłowski (1792099), Mateusz Nowak (2424970)   +3 more
core   +1 more source

Synthetic Strategies toward Lysergic Acid Diethylamide: Ergoline Synthesis via α‑Arylation, Borrowing Hydrogen Alkylation, and C–H Insertion

Lysergic acid diethylamide (LSD), a semisynthetic ergoline alkaloid analogue and hallucinogen, is a potent psychoplastogen with promising therapeutic potential.
Lee E. Dunlap (5135045), David E. Olson (1987003), Jeremy R. Tuck (10844876)   +2 more
core   +1 more source

Synthetic Strategies Towards LSD and Discovery of Isotryptamine Isosteres of Ergoline Alkaloids

, 2023
Neuronal atrophy and decreased dendritic spine density in the cortex are key pathological features of a variety of neuropsychiatric disorders. Lysergic acid diethylamide (LSD), a semi-synthetic ergoline alkaloid and psychoplastogen, possesses the ...
Tuck, Jeremy Ryan
core  

An Innovative Integrated Method in MHD Design of Electromagnetic Stirrers

, 2008
Design and optimization of stirrers are complex activities for two main reasons: there is no standard in steelmaking plants, meaning that a personalized design is typically required, and it is not possible to accurately predict the flow induced to liquid
NOBILE, ENRICO, Persi C., SPAGNUL, STEFANO, Battistutto B.   +3 more
core  

Towards a biophysical understanding of hallucinogen action

, 2007
The serotonin 2A (5-HT2A) receptor is necessary for the psychopharmacological actions of the serotonergic hallucinogens such as LSD. An exploration of the biophysical actions of hallucinogens at the 5-HT2A receptor may be useful in understanding their ...
Braden, Michael Robert
core  

Endophyte in Tall Fescue: Impact on Horses and Cattle

, 2011
Tall fescue [Lolium arundinaceum (Schreb.) Darbysh.] is an introduced cool-season perennial grass from Europe. Originally imported for regularly flooded pastures, tall fescue is now widespread across the United States due to its adaptability of a wide ...
Cotton, Krista, Smith, S. Ray
core  

A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics. [PDF]

Biology (Basel), 2023
Banushi B, Polito V.
europepmc   +1 more source