Results 31 to 40 of about 1,990 (193)

The impact of biological sex and stroke volume constituents on heterogeneity in the Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$ relationship and skeletal muscle saturation during cycling

open access: yesExperimental Physiology, Volume 111, Issue 10, Page 4382-4396, 1 October 2026.
Abstract Interindividual variability in the cardiac output (Q̇$\dot{Q}$) to the rate of oxygen consumption (V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) slope (Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) in healthy males is related to stroke volume (SV); however, the impact of differences in left ventricular (LV) structure and function as well as ...
Adam N. Di Salvo   +4 more
wiley   +1 more source

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.

open access: yes, 2008
Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pK(d) r sst(1)>9) and selectivity (>1000-fold for h sst(1) over h sst(2)-h sst(5)) for the ...
Enz, Albert   +7 more
core   +1 more source

Validity and Feasibility of the Constant‐Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy

open access: yesThoracic Cancer, Volume 17, Issue 17, September 2026.
The constant‐load cycle endurance test (CET) demonstrated feasibility and validity in lung cancer patients undergoing thoracic radiation therapy. CET may provide complementary information to the 6‐min walk test when evaluating rehabilitation outcomes.
Junghwa Do   +7 more
wiley   +1 more source

Pergolide elevation of MHPG sulphate concentration in rat hypothalamus blocked by spiperone and mimicked by other dopamine agonists

open access: yes, 1985
Pergolide increased the concentration of MHPG sulphate (3-methoxy-4-hydroxy-phenylethylene glycol sulphate) in rat hypothalamus, and the increase was prevented by pretreatment with spiperone, a dopamine antagonist.
Susan K Hemrick-Luecke   +3 more
core   +1 more source

Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once‐Weekly Basal Insulin Icodec

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8523-8532, September 2026.
ABSTRACT Aims To investigate glucose levels and hypoglycaemia risk during exercise or fasting in adults with type 2 diabetes (T2D) treated with once‐weekly basal insulin icodec. Materials and Methods Thirty basal insulin‐treated, physically active individuals with T2D (18–75 years, glycated haemoglobin ≤ 75 mmol/mol, peak oxygen uptake > 20 mL/kg/min ...
Thomas R. Pieber   +10 more
wiley   +1 more source

Differential effects of central blood volume loading and unloading on pulmonary diffusing capacity in humans

open access: yesThe Journal of Physiology, Volume 604, Issue 18, Page 7957-7970, 15 September 2026.
Abstract figure legend Central blood volume (CBV) is a key haemodynamic determinant of pulmonary diffusing capacity for carbon monoxide (DLCO) and its components, capillary blood volume (Vc) and membrane diffusing capacity (Dm,CO). However the contribution of CBV to DLCO regulation remains poorly defined. We investigated the effects of graded increases
Andrew W. D'Souza   +8 more
wiley   +1 more source

Ergot alkaloids and summary of biosynthesis pathway.

open access: yes, 2013
(A) Ergoline alkaloid biosynthesis pathways in the Clavicipitaceae. Arrows indicate one or more steps catalyzed by products of genes indicated. Arrows and genes in blue indicate steps in synthesis of the first fully cyclized intermediate (skeleton ...
Jennifer L. Wiseman (383659)   +54 more
core   +1 more source

Chronic, self‐reported fatigue in adult immunotherapy patients and healthy controls: No association with cardiopulmonary exercise testing parameters

open access: yesPhysiological Reports, Volume 14, Issue 17, September 2026.
Abstract This study examined whether cardiopulmonary exercise test (CPET) performance parameters are associated with chronic cancer‐related fatigue in patients receiving immunotherapy checkpoint inhibitors (ICI) and healthy controls. Also, the differences in energy expenditure of steady‐state cycling and gross efficiency were assessed during submaximal
Damir Zubac   +3 more
wiley   +1 more source

Cytokine Gene Variants Are Associated With Aerobic Fitness‐Related, Hematological, and Metabolic Traits in Healthy Adults

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Analysis of ~1000 adults shows cytokine gene variants are more strongly associated with hematological and metabolic traits than fitness classification. IL6 and TNF‐α variants link to iron status and aerobic fitness, with exploratory multi‐locus effects involving IL15. ABSTRACT Genetic variation in cytokine genes may influence cytokine‐related signaling,
Kinga Humińska‐Lisowska   +6 more
wiley   +1 more source

Derivatives as 5HT1A receptor ligands-past and present.

open access: yes, 2005
A review. Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT)
SANTAGADA, VINCENZO   +3 more
core   +1 more source

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