Results 41 to 50 of about 712 (172)

Chronic, self‐reported fatigue in adult immunotherapy patients and healthy controls: No association with cardiopulmonary exercise testing parameters

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract This study examined whether cardiopulmonary exercise test (CPET) performance parameters are associated with chronic cancer‐related fatigue in patients receiving immunotherapy checkpoint inhibitors (ICI) and healthy controls. Also, the differences in energy expenditure of steady‐state cycling and gross efficiency were assessed during submaximal
Damir Zubac, Timo Sonntag, Diana Kranjc, Freerk T. Baumann   +3 more
wiley   +1 more source

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.

, 2008
Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pK(d) r sst(1)>9) and selectivity (>1000-fold for h sst(1) over h sst(2)-h sst(5)) for the ...
Enz, Albert, Neumann, Peter, Schoeffter, Philippe, Pfaeffli, Paul, Hurth, Konstanze, Langenegger, Daniel, Hoyer, Daniel, Troxler, Thomas J.   +7 more
core   +1 more source

PhD [PDF]

, 2008
dissertationEarlier studies have demonstrated the peroxidase oxidation of the delta8-ergolines agroclavine and elymoclavine to their respective 10-hydroxy-delta9, and other derivatives.
Choong, Tung-Chung.
core   +2 more sources

Cytokine Gene Variants Are Associated With Aerobic Fitness‐Related, Hematological, and Metabolic Traits in Healthy Adults

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Analysis of ~1000 adults shows cytokine gene variants are more strongly associated with hematological and metabolic traits than fitness classification. IL6 and TNF‐α variants link to iron status and aerobic fitness, with exploratory multi‐locus effects involving IL15. ABSTRACT Genetic variation in cytokine genes may influence cytokine‐related signaling,
Kinga Humińska‐Lisowska, Barkın Bıçakçı, Monika Michałowska‐Sawczyn, Piotr Aschenbrenner, Alison V. September, Patrizia Proia, Agata Leońska‐Duniec   +6 more
wiley   +1 more source

Structural Features for Functional Selectivity at Serotonin Receptors [PDF]

, 2013
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Han, G. W., Liu, W., Roth, B. L., Vardy, E., Katritch, V., Jiang, Y., McCorvy, J. D., Wang, C., Stevens, R. C., Wacker, D., Xu, H. E., Chu, M., Cherezov, V., Siu, F. Y., Huang, X.-P.   +14 more
core   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

A 12‐week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors

European Journal of Sport Science, Volume 26, Issue 7, July 2026.
ABSTRACT Physical activity (PA) is key to improve the prognosis of patients with chronic coronary syndrome (CCS). This study investigated changes in movement behaviors (MB), obesity markers, cardiorespiratory fitness (VO2peak), cardiometabolic risk (CMR), and brain‐derived neurotrophic factor (BDNF) and whether changes in MB are associated with VO2peak,
Antje Ullrich, Martin Bahls, Lisa Voigt, Stephanie Könemann, Marcus Dörr, Susanne Wurm, Sabina Ulbricht   +6 more
wiley   +1 more source

Pergolide elevation of MHPG sulphate concentration in rat hypothalamus blocked by spiperone and mimicked by other dopamine agonists

, 1985
Pergolide increased the concentration of MHPG sulphate (3-methoxy-4-hydroxy-phenylethylene glycol sulphate) in rat hypothalamus, and the increase was prevented by pretreatment with spiperone, a dopamine antagonist.
Susan K Hemrick-Luecke, Kenneth W Perry, Ray W Fuller, Richard E Toomey   +3 more
core   +1 more source

Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High‐Flow O2 Therapy in Fibrotic Interstitial Lung Disease: A Pilot Physiological Study

Respirology, Volume 31, Issue 7, Page 732-744, July 2026.
We tested the respective effect of high‐flow and supplemental O2 from nasal high‐flow O2 therapy (NHFO2) on dyspnea and exercise tolerance in fibrotic interstitial lung disease. Supplemental O2 and NHFO2 (but not high‐flow) provided improvements in these outcomes at “iso‐O2 saturation” due to reduced ventilatory requirements.
Sarah Thivent, Marylise Ginoux, Samuel Verges, Frédéric Hérengt, Mathieu Marillier   +4 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source