Results 41 to 50 of about 1,990 (193)
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le +8 more
wiley +1 more source
European Journal of Sport Science, Volume 26, Issue 7, July 2026.ABSTRACT Physical activity (PA) is key to improve the prognosis of patients with chronic coronary syndrome (CCS). This study investigated changes in movement behaviors (MB), obesity markers, cardiorespiratory fitness (VO2peak), cardiometabolic risk (CMR), and brain‐derived neurotrophic factor (BDNF) and whether changes in MB are associated with VO2peak,
Antje Ullrich +6 more
wiley +1 more source
Respirology, Volume 31, Issue 7, Page 732-744, July 2026.We tested the respective effect of high‐flow and supplemental O2 from nasal high‐flow O2 therapy (NHFO2) on dyspnea and exercise tolerance in fibrotic interstitial lung disease. Supplemental O2 and NHFO2 (but not high‐flow) provided improvements in these outcomes at “iso‐O2 saturation” due to reduced ventilatory requirements.
Sarah Thivent +4 more
wiley +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists
British Journal of Pharmacology, Volume 183, Issue 14, Page 3935-3949, July 2026.Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Receptor-Based Pharmacophores for Serotonin 5-HT7R AntagonistsImplications to Selectivity
, 2016 A set of 31 diversified 5-HT7 receptor antagonists was automatically docked to a conformational ensemble of rhodopsin-based 5-HT7R models (flexible docking). It was found that ergolines, aporphines, and tricyclic psychotropic agents were always docked in
Andrzej J. Bojarski (499184) +3 more
core +1 more source
Towards a biophysical understanding of hallucinogen action
, 2007 The serotonin 2A (5-HT2A) receptor is necessary for the psychopharmacological actions of the serotonergic hallucinogens such as LSD. An exploration of the biophysical actions of hallucinogens at the 5-HT2A receptor may be useful in understanding their ...
Braden, Michael Robert
core +1 more source
Arylpiperazine derivatives as serotoninergic ligands
, 2009 Serotonin is a neuromediator well known for its implication in mood regulation, anxiety, depression,insomnia as well as in normal human function such as sleep, sexual activity and appetite and recently it was demonstrated its involvement in the ...
SEVERINO B +9 more
core +1 more source
Endophyte in Tall Fescue: Impact on Horses and Cattle [PDF]
, 2011 Tall fescue [Lolium arundinaceum (Schreb.) Darbysh.] is an introduced cool-season perennial grass from Europe. Originally imported for regularly flooded pastures, tall fescue is now widespread across the United States due to its adaptability of a wide ...
Cotton, Krista, Smith, S. Ray
core