Results 41 to 50 of about 674 (175)
British Journal of Pharmacology, Volume 183, Issue 14, Page 4058-4071, July 2026.Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito +6 more
wiley +1 more source
Ergot alkaloids and summary of biosynthesis pathway.
, 2013 (A) Ergoline alkaloid biosynthesis pathways in the Clavicipitaceae. Arrows indicate one or more steps catalyzed by products of genes indicated. Arrows and genes in blue indicate steps in synthesis of the first fully cyclized intermediate (skeleton ...
Jennifer L. Wiseman (383659) +54 more
core +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.In patients with pulmonary vascular diseases (PAH and CTEPH), supplemental oxygen (FiO2 0.3), compared to room air (FiO2 0.21) improved peak exercise capacity (peak V̇O2), peak sustainable exercise (V̇O2 at GET), and V̇O2 kinetics and the onset of exercise.
Shir Kadosh +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5229-5239, June 2026.ABSTRACT Aim Cardiorespiratory fitness is often impaired in individuals with type 1 diabetes. While physiological determinants have been studied, psychological barriers such as fear of hypoglycaemia remain underexplored. We hypothesised that glycaemic factors including HbA1c, diabetes duration, the presence of microvascular complications, and fear of ...
Arne Kooistra +6 more
wiley +1 more source
The total syntheses of ring -A substituted ergolines
, 1998 Three types of ergolines, having a substituent in ring A were designed and their total syntheses were attempted. N-substituted 12-methoxyergolines were synthesized as potential serotonergic agents to test the hypothesis of bioisosterism between the C8 ...
Lee, Sunkyung
core
Does Aerobic Capacity Protect Against Stress? Insights From Two Stress‐Induction Paradigms
Psychophysiology, Volume 63, Issue 6, June 2026.ABSTRACT Prior evidence suggests that individuals with higher fitness exhibit attenuated endocrine and autonomic responses to acute psychological and physical stressors. However, it remains unclear whether this stress‐buffering effect depends on the type of stressor.
Peter Raidl +5 more
wiley +1 more source
Derivatives as 5HT1A receptor ligands-past and present.
, 2005 A review. Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT)
SANTAGADA, VINCENZO +3 more
core +1 more source
Experimental Physiology, Volume 111, Issue 6, Page 2963-2974, 1 June 2026.Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger +10 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 11, June 2026.LL‐BFR resistance exercise offers a promising alternative to traditional high‐load resistance training by reducing respiratory demand and perceived breathing effort, making it particularly beneficial for individuals with compromised respiratory function.
Manuel Kuhn +10 more
wiley +1 more source
Structural Features for Functional Selectivity at Serotonin Receptors
, 2013 Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Han, G. W. +14 more
core +1 more source