Results 11 to 20 of about 1,990 (193)

Stimulant and hallucinogenic novel psychoactive substances; an update [PDF]

, 2023
Introduction: The renewed interest in considering a range of stimulants, psychedelics and dissociatives as therapeutics emphasizes the need to draft an updated overview of these drugs’ clinical and pharmacological issues.
Amira Guirguis, Scherbaum, Norbert, Vento, Alessandro, Guirguis, Amira, Schifano, Fabrizio   +4 more
core   +3 more sources

5-HT_2A receptors: Pharmacology and functional selectivity. [PDF]

Pharmacol Rev
Serotonin 5-HT receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain ...
Cummins BR, Billac GB, Nichols DE, Nichols CD.   +3 more
europepmc   +2 more sources

Two new dopamine agonists that are long acting in vivo but short acting in vitro

, 2016
The effects of two new ergolines, pergolide and CH29-717, on prolactin secretion in vitro and in vivo were compared with those of bromocriptine. Both ergolines had in vitro potencies similar to that of bromocriptine, but had a shorter duration of action.

core   +2 more sources

Synthetic studies on polycyclic indole alkaloids [PDF]

, 2006
The first part of this work details the formal total synthesis of HKI 0231B and the first total synthesis of both demethyl HKI 0231A and demethyl HKI 0231B. The formal synthesis used TBAF as a mild reagent to construct the indole.
Wu, Tao
core   +1 more source

Sex differences in the prefrontal cortex and muscle oxygenation during exercise until exhaustion in endurance‐trained individuals

Experimental Physiology, EarlyView.
Abstract figure legend During cardiopulmonary exercise testing, the decline in oxygenation in the prefrontal cortex of women is striking. This crucial brain area is directly involved in planning motor tasks. The decline is particularly pronounced at higher exercise intensities, especially after reaching the respiratory compensation point or anaerobic ...
Daniel Ramos‐López, Raúl Caulier‐Cisterna, Benjamín Díaz‐Ortiz, Cristóbal Baumann‐Biancani, Kamilo Hunger‐Abbott, Matías Herrera‐Matas, Andrés Vega‐Moraga, Vitor A. Lira, Maximiliano Espinosa‐Ramírez, Karol Ramírez‐Parada, Luigi Gabrielli‐Nervi, Hugo E. Verdejo, Felipe Contreras‐Briceño   +12 more
wiley   +1 more source

Postexercise muscle oxygen uptake kinetics in older breast cancer survivors and healthy individuals: Association with myosteatosis

Experimental Physiology, EarlyView.
Abstract Reduced cardiorespiratory fitness is common among breast cancer survivors and, although traditionally attributed to cardiac dysfunction, might also be related to peripheral skeletal muscle abnormalities. We examined peak and submaximal plantar‐flexion exercise and recovery kinetics for lower‐leg oxygen uptake (V̇O2${\dot V_{{{\mathrm{O}}_2}}}$)
Nathan R. Weeldreyer, Thomas J. McMurtry, Stephen J. Foulkes, Amanda Shewman, Edith Pituskin, Rachel J. Skow, Richard B. Thompson, Justin Grenier, Deirdre E. O'Neill, Robert C. Welsh, Mark J. Haykowsky, Corey R. Tomczak   +11 more
wiley   +1 more source

Electrochemical synthesis of 2-haloergolines

, 1987
Regiosclective halogenation (chlorination, bromination, iodination) of several ergolines to the corresponding 2-halo derivatives was performed in moderate to good yields by potential controlled electrolysis at platinum in acetonitrile in the presence of ...
G. FIORI, B. DANIELI, G. PALMISANO, G. LESMA   +3 more
core   +1 more source

Structural Features for Functional Selectivity at Serotonin Receptors [PDF]

, 2013
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Han, G. W., Liu, W., Roth, B. L., Vardy, E., Katritch, V., Jiang, Y., McCorvy, J. D., Wang, C., Stevens, R. C., Wacker, D., Xu, H. E., Chu, M., Cherezov, V., Siu, F. Y., Huang, X.-P.   +14 more
core   +1 more source

Identification of the individual cardiac contraction threshold during high‐frame‐rate stress echocardiography

Experimental Physiology, EarlyView.
Abstract The clinical assessment of cardiovascular function during exercise using stress echocardiography is essential for accurate cardiac diagnosis. However, normal limitations of cardiac deformation responses to increasing physical exertion remain poorly understood.
Fabian Spahiu, Max Hagemann, Michelle Ottlik, Moritz Lampkemeyer, Eric J. Stöhr   +4 more
wiley   +1 more source

Impact of 14 days of head‐down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults

Experimental Physiology, EarlyView.
Abstract Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults.
Jean‐Christophe Lagacé, Philippe St‐Martin, Mariano Avino, Ahmed Ghachem, Guy Hajj‐Boutros, Jose A. Morais, Jamie S. McPhee, Karen Lambert, Eléonor Riesco, Isabelle J. Dionne   +9 more
wiley   +1 more source