Results 11 to 20 of about 609 (136)

Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once‐Weekly Basal Insulin Icodec

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate glucose levels and hypoglycaemia risk during exercise or fasting in adults with type 2 diabetes (T2D) treated with once‐weekly basal insulin icodec. Materials and Methods Thirty basal insulin‐treated, physically active individuals with T2D (18–75 years, glycated haemoglobin ≤ 75 mmol/mol, peak oxygen uptake > 20 mL/kg/min ...
Thomas R. Pieber, Harpreet S. Bajaj, Gabriele Fluhr, Klara R. Klein, Thaís M. Pagliaro Rocha, Harald Sourij, Eva Svehlikova, Keerthana Udupa, Sara K. Watt, Maria Willerslev‐Olsen, Rasmus Ribel‐Madsen   +10 more
wiley   +1 more source

Genetics of ergoline alkaloid formation in Penicillium roquefortii [PDF]

Applied and Environmental Microbiology, 1985
Auxotrophic, spore color, and alkaloid biosynthetic mutants of Penicillium roquefortii were selected after N-methyl-N'-nitro-N-nitrosoguanidine treatment. Diploids were obtained via protoplast fusion techniques, and the segregants from a diploid were genetically analyzed. The data demonstrated the potential of parasexual recombination in this organism.
S L, Hong, J E, Robbers
openaire   +2 more sources

Sex differences in the prefrontal cortex and muscle oxygenation during exercise until exhaustion in endurance‐trained individuals

Experimental Physiology, EarlyView.
Abstract figure legend During cardiopulmonary exercise testing, the decline in oxygenation in the prefrontal cortex of women is striking. This crucial brain area is directly involved in planning motor tasks. The decline is particularly pronounced at higher exercise intensities, especially after reaching the respiratory compensation point or anaerobic ...
Daniel Ramos‐López, Raúl Caulier‐Cisterna, Benjamín Díaz‐Ortiz, Cristóbal Baumann‐Biancani, Kamilo Hunger‐Abbott, Matías Herrera‐Matas, Andrés Vega‐Moraga, Vitor A. Lira, Maximiliano Espinosa‐Ramírez, Karol Ramírez‐Parada, Luigi Gabrielli‐Nervi, Hugo E. Verdejo, Felipe Contreras‐Briceño   +12 more
wiley   +1 more source

Postexercise muscle oxygen uptake kinetics in older breast cancer survivors and healthy individuals: Association with myosteatosis

Experimental Physiology, EarlyView.
Abstract Reduced cardiorespiratory fitness is common among breast cancer survivors and, although traditionally attributed to cardiac dysfunction, might also be related to peripheral skeletal muscle abnormalities. We examined peak and submaximal plantar‐flexion exercise and recovery kinetics for lower‐leg oxygen uptake (V̇O2${\dot V_{{{\mathrm{O}}_2}}}$)
Nathan R. Weeldreyer, Thomas J. McMurtry, Stephen J. Foulkes, Amanda Shewman, Edith Pituskin, Rachel J. Skow, Richard B. Thompson, Justin Grenier, Deirdre E. O'Neill, Robert C. Welsh, Mark J. Haykowsky, Corey R. Tomczak   +11 more
wiley   +1 more source

Identification of the individual cardiac contraction threshold during high‐frame‐rate stress echocardiography

Experimental Physiology, EarlyView.
Abstract The clinical assessment of cardiovascular function during exercise using stress echocardiography is essential for accurate cardiac diagnosis. However, normal limitations of cardiac deformation responses to increasing physical exertion remain poorly understood.
Fabian Spahiu, Max Hagemann, Michelle Ottlik, Moritz Lampkemeyer, Eric J. Stöhr   +4 more
wiley   +1 more source

Impact of 14 days of head‐down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults

Experimental Physiology, EarlyView.
Abstract Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults.
Jean‐Christophe Lagacé, Philippe St‐Martin, Mariano Avino, Ahmed Ghachem, Guy Hajj‐Boutros, Jose A. Morais, Jamie S. McPhee, Karen Lambert, Eléonor Riesco, Isabelle J. Dionne   +9 more
wiley   +1 more source

The impact of biological sex and stroke volume constituents on heterogeneity in the Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$ relationship and skeletal muscle saturation during cycling

Experimental Physiology, EarlyView.
Abstract Interindividual variability in the cardiac output (Q̇$\dot{Q}$) to the rate of oxygen consumption (V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) slope (Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) in healthy males is related to stroke volume (SV); however, the impact of differences in left ventricular (LV) structure and function as well as ...
Adam N. Di Salvo, Sinan Osman, Jacob L. Schwartz, Nino Nikolovski, Robert F. Bentley   +4 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Post‐exercise ketone supplementation improves endurance performance and mitochondrial adaptations during an 8‐week endurance training intervention

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐eight trained males completed 8 weeks of supervised indoor cycling training, receiving post‐exercise and pre‐sleep ketone monoester (KE, n = 14) or isocaloric placebo (CON, n = 14). Both groups improved 30 min time‐trial performance with training, but KE achieved a 4% higher power output than CON at the end of the training
Ruben Robberechts, Youri Bekhuis, Myrthe Stalmans, Wout Lauriks, Martijn Kusters, Karim Taha, Thomas Rosseel, Guido Claessen, Chiel Poffé   +8 more
wiley   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source