Results 91 to 100 of about 8,556 (199)

Use of ergotamine: Do physicians in Colombia know how to prescribe it?

open access: yesNeurología (English Edition), 2014
Introduction: Ergot derivatives are drugs with vasoconstrictor effects that are used to abort migraine attacks. This study aims to determine how ergotamine derivatives are prescribed by physicians in Colombia, find variables associated with inappropriate
J.E. Machado-Alba, C.D. Morales-Plaza
doaj   +1 more source

Drugs Affecting 5-HT Systems [PDF]

open access: yes, 2013
Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core  

Ergotaminine

open access: yesActa Crystallographica Section E, 2012
The title compound {systematic name: (6aR,9S)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide}, C33H35N5O5, was formed
Franziska Emmerling   +4 more
doaj   +1 more source

Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines

open access: yesActa Pharmaceutica Sinica B
Ergopeptines or their derivatives are widely used for treating neurodegenerative and cerebrovascular diseases. The nonribosomal peptide synthetase—d-lysergyl peptide synthetase A (LPSA) determines ergopeptine formation but the detailed mechanism remains ...
Jing-Jing Chen   +5 more
doaj   +1 more source

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study. [PDF]

open access: yes, 2018
BackgroundIn a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6 mg dose.
Brand-Schieber, Elimor   +3 more
core   +1 more source

Solid substrate mediated changes in ergot alkaloid spectra in solid state fermentation system [PDF]

open access: yes, 1993
Use of different solid substrates resulted in minor alterations in total alkaloid production by #Claviceps purpurea$ 1029c in solid state fermentation system but the changes in the spectra of ergot alkaloids were of significantly higher magnitudes ...
Lonsane, B.K.   +3 more
core  

Management Of Acute Migraine

open access: yesAnnals of Indian Academy of Neurology, 2002
Pharmacotherapy for migraine involves treatment for the acute attack as well as using long-term prophylaxis in order to reduce the frequency and severity of the attacks. Based on severity, there are a number of drugs available to treat the acute attacks.
Mehndiratta M
doaj  

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