Results 91 to 100 of about 5,187 (196)

Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines

Acta Pharmaceutica Sinica B
Ergopeptines or their derivatives are widely used for treating neurodegenerative and cerebrovascular diseases. The nonribosomal peptide synthetase—d-lysergyl peptide synthetase A (LPSA) determines ergopeptine formation but the detailed mechanism remains ...
Jing-Jing Chen, Ting Gong, Wei-Bo Wang, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu   +5 more
doaj   +1 more source

Sensitive ergotamine determination in pharmaceuticals and biological samples using cloud point preconcentration and spectrofluorimetric detection

, 2013
A new cloud point extraction (CPE) method for ergotamine analysis using fluorimetric detection is described. Ergotamine from an aqueous solution was preconcentrated into a smaller surfactant-rich phase using nonionic surfactant polyoxyethylene(7.5 ...
Gomez, Maria Roxana Anabel, Fernandez, Liliana Patricia, Wang, Chien Chun   +2 more
core   +1 more source

Ergotamine structure and schematic representation of the position of micro-switches in the ergotamine-serotonin receptor complexes.

, 2014
X-crystal structures are shown in thick sticks representation whereas simulation shows frames every 200 ns of the 2.5 µs concatenated trajectories.
Ferran Sanz (89706), Manuel Pastor (147919), Jana Selent (147923), Maria Martí-Solano (644060)   +3 more
core   +1 more source

Ergotamine-induced pleural and pericardial effusion successfully treated with colchicine

, 2013
A 83-year-old woman was admitted to hospital with chest pain, fever, dry cough and palpitations. Chest X-ray revealed a pleural effusion, assumed to be caused by cardiac failure and respiratory infection. Despite treatment with antibiotics and diuretics,
Tournoy, Jos, Helsen, V., Spriet, Isabel, Fagard, Katleen, Boonen, Steven, Decoutere, L.   +5 more
core   +1 more source

An unusual cause of chest pain: Acute coronary syndrome following administration of ergotamine tartrate

, 2012
For many years, ergotamine has been used for the acute treatment of migraine. Ergotamine may produce coronary vasospasm, which is often associated with ischemic electrocardiography changes and angina pectoris.
AYTEMİR, KUDRET, OKUTUCU, SERCAN, Kabakci, Giray, KARAKULAK, UĞUR NADİR   +3 more
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Some Effects of Ergotamine Tartrate Upon Lactation in the Rat

, 1956
A study was made of the direct effects of ergotamine tartrate upon the lactating rat, her young, and upon milk secretion from her mammary glands. The drug was administered to lactating rats at dosage of 3 mg/kg/day on each of days 9–12 postpartum.
Clark E. Grosvenor
core   +1 more source

An electron microscopic and biochemical study of the effects of cyclic 3', 5'- AMP, ergotamine or propanolol on the lysosomes of newborn rat hepatocytes [PDF]

, 1991
The effects of cyclic 3', 5'-AMP, ergotamine or propranolol on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry.
Kotoulas, Angeliki O., Kalamidas, Stefanos, Kotoulas, Othon B.   +2 more
core  

Resolution and quantification challenge of modern chemometric models in the determination of anti-migraine tablets containing ergotamine, caffeine, acetaminophen, and metoclopramide

, 2017
Unique mixture of ergotamine (ERG), metoclopramide (MET), caffeine (CAF) and the study presents a comparison between five multivariate models in the determination of the paracetamol (PAR) in laboratory mixtures and in pharmaceutical formulations.
Mahmoud M. Elkhoudary, Randa A. Abdel Salam, Ghada M. Hadad   +2 more
core   +1 more source

Strategies for Improved Modeling of GPCR-Drug Complexes: Blind Predictions of Serotonin Receptors Bound to Ergotamine

, 2016
The recent increase in the number of atomic-resolution structures of G protein-coupled receptors (GPCRs) has contributed to a deeper understanding of ligand binding to several important drug targets.
Anirudh Ranganathan (1451149), Jens Carlsson (584038), David Rodríguez (1632292)   +2 more
core   +1 more source

Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine

, 2003
p.20-29Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 rizatriptan 10 ...
Christie, S.
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