Results 81 to 90 of about 8,556 (199)
Nano Select, Volume 7, Issue 1, January 2026.Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini +3 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, Volume 66, Issue 1, Page 172-182, January 2026.Abstract Objectives/Background Reimbursement criteria for anti‐calcitonin gene‐related peptide (CGRP) monoclonal antibodies (MAbs) typically rely on predefined reductions in monthly migraine days (MMD). However, this approach may fail to capture the full spectrum of treatment benefits, potentially leading to premature discontinuation in patients ...
Albert Muñoz‐Vendrell +7 more
wiley +1 more source
Ischemic Colitis Secondary to Ergotamine Use: A Case Study
Case Reports in Gastroenterology, 2011 A 48-year-old woman with a history of chronic migraines, initially admitted for inpatient management of intractable migraine headaches, developed new onset abdominal pain, hypotension, and diarrhea on hospital day number ten.
Regina E. Rodman +3 more
doaj +1 more source
Prevalence, characteristics and management of headache experienced by people with schizophrenia and schizoaffective disorder: a cross sectional cohort study [PDF]
, 2017 Objective: Headache is the most common type of pain reported by people with schizophrenia. This study aimed to establish prevalence, characteristics and management of these headache.
Connaughton, J, Wand, B
core +2 more sources
Identifying potential drug targets in the kinomes of two monogenean species
HelminthologiaProtein kinases are enzymes involved in essential biological processes such as signal transduction, transcription, metabolism, and the cell cycle. Human kinases are targets for several drugs approved by the US Food and Drug Administration. Therefore, the
Caña-Bozada V. H. +4 more
doaj +1 more source
Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]
, 2010 Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica +8 more
core +1 more source
Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment
Discover OncologyColorectal cancer is one of the common cancers worldwide and the second leading cause of cancer-related death. The current treatment has the inherent drawbacks and there is a need of developing a new treatment.
Bavya Chandrasekhar +5 more
doaj +1 more source
Serotonin receptors: Subtypes, functional responses and therapeutic relevance [PDF]
, 1995 Recent, rapid progress in the molecular biology of serotonin (5-HT) receptors requires conceptual re-thinking with respect to receptor classification.
Saxena, P.R. (Pramod Ranjan)
core +1 more source
Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]
, 2019 In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie +3 more
core +2 more sources
Cases of ergotism in livestock and associated ergot alkaloid concentrations in feed
Frontiers in Chemistry, 2015 Ergot-induced disease was known long before Biblical times and has been the root cause for countless human epidemics spanning from the early fourteenth century to the late sixteenth century.
A. Morrie Craig +2 more
doaj +1 more source