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Serotonin Can Stimulate Vasorelaxation in Ovine Lateral Saphenous Veins Precontracted With Ergovaline [PDF]

Journal of Animal Science
Abstract The ergot alkaloid ergovaline is a potent vasoconstrictor. Previous research has shown that ergovaline can bind serotonin (5-HT) receptors and elicit vasoconstrictive activity. Three experiments were conducted to evaluate 5-HT as a vasorelaxant in the ovine saphenous artery and vein. Blood vessels were collected from mixed-breed
Huihua Ji, James L Klotz, Susan Duckett
exaly   +4 more sources

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A gene cluster for ergovaline biosynthesis

NZGA: Research and Practice Series, 2007
Some strains of Epichloë and Neotyphodium endophytes produce the ergot alkaloid ergovaline, which is implicated in livestock toxicoses caused by ingestion of endophyte-infected grasses.
D.J. Fleetwood, B. Scott, G.A. Lane, A. Tanaka, R.D. Johnson   +4 more
openaire   +1 more source

ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS

In Vitro Cellular and Developmental Biology--Animal, 2005
Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
openaire   +2 more sources

Ergovaline Does Not Alter the Severity of Ryegrass Staggers Induced by Lolitrem B

New Zealand Veterinary Journal, 2018
To investigate a possible interaction between lolitrem B and ergovaline by comparing the incidence and severity of ryegrass staggers in sheep grazing ryegrass (Lolium perenne) containing lolitrem B or ryegrass containing both lolitrem B and ergovaline.Ninety lambs, aged approximately 6 months, were grazed on plots of perennial ryegrass infected with ...
Chikako van Koten, Wade Mace, Sarah Finch   +2 more
exaly   +3 more sources

Ergovaline levels in cultivars of Festuca arundinacea

Animal Feed Science and Technology, 2001
This work was funded by the “Junta de Castilla y Leon “ (CSI3/98). Beatriz R. Vazquez de Aldana was supported by a Research Contract from the Spanish “Ministerio de Ciencia y Tecnologia”.
B.R. Vázquez de Aldana, A. Garcı́a Ciudad, I. Zabalgogeazcoa, B. Garcı́a Criado   +3 more
openaire   +1 more source

Microbiomic Comparison of the Intestine of the Earthworm Eisenia fetida Fed Ergovaline

Current Microbiology, 2009
Tall fescue toxicosis and ergot alkaloids cost U.S. livestock producers approximately one billion dollars in annual livestock production loss annually. Ergovaline (EV) is the tall fescue alkaloid primarily responsible for clinical disease in livestock.
Rogan M, Rattray, Sudeep, Perumbakkam, Forrest, Smith, A Morrie, Craig   +3 more
openaire   +2 more sources

Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells

Journal of Animal Science, 1995
Ergovaline inhibition of radioligand binding to the D2 dopamine receptor and ergot alkaloid inhibition of vasoactive intestinal peptide (VIP)-stimulated cyclic AMP production in GH4ZR7 cells, stably transfected with a rat D2 dopamine receptor, were evaluated. Ergovaline inhibition of the binding of the D2-specific radioligand, [3H]YM-09151-2, exhibited
B T, Larson, M D, Samford, J M, Camden, E L, Piper, M S, Kerley, J A, Paterson, J T, Turner   +6 more
openaire   +2 more sources

Ergovaline Levels in Tall Fescue and Its Effect on Performance of Lactating Cows

Animal Feed Science and Technology, 2007
Abstract To investigate the effects of ergovaline on milk production of lactating dairy cows, a survey and feeding trial were conducted. In the survey, 25 samples of imported tall fescue (Festuca arundinacea) hay were collected and analyzed for ergovaline.
K K Park
exaly   +2 more sources

Evidence that ergovaline acts on serotonin receptors

Life Sciences, 1993
Ergovaline is a potent vasoconstrictor of isolated bovine uterine and umbilical arteries. Contractions to ergovaline were slow to develop and required 120 min or more to reach their maximum effect. Tissues contracted to ergovaline did not relax over a 3 hr period despite repeated changing of the bath fluid with fresh Krebs solution.
openaire   +2 more sources