Results 171 to 180 of about 317,386 (198)

Cisplatin induces platelet apoptosis through the ERK signaling pathway

Thrombosis Research, 2012
Cisplatin (cis-diamminedichloroplatinum II) is one of the most widely used anti-tumor agents. However, cisplatin-based chemotherapy is usually accompanied by adverse side effects such as thrombocytopenia, and the mechanism remains unclear. Here we show that cisplatin induced several platelet apoptotic events including up-regulation of Bax and Bak, down-
Weilin, Zhang, Lili, Zhao, Jun, Liu, Juan, Du, Zhicheng, Wang, Changgeng, Ruan, Kesheng, Dai   +6 more
openaire   +2 more sources

The RAS/RAF/ERK signal transduction pathway

1997
Abstract The importance of RAS proteins in human cancer was established in 1982, when the first human oncogene was recognized to be a mutant version of a normal H-RAS allele (1). These early observations prompted exhaustive efforts to identify effectors of RAS proteins, and so to understand their precise molecular function. These efforts
Susan G Macdonald, Frank McCormick
openaire   +1 more source

Activated EGF Receptor may balance ERK-inhibitory network signalling pathways

Cellular Signalling, 2006
In the COS-7 cell signalling network high levels of cAMP produced, for example, by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor (BKR) may affect epidermal growth factor receptor (EGFR)-mediated activation of extracellular signal-stimulated kinase (ERK). In contrast, co-stimulation of either beta2-AR or B2R with EGFR
Sabine, Hanke, Christina, Valkova, Jörg, Stirnweiss, Sebastian, Drube, Claus, Liebmann   +4 more
openaire   +2 more sources

Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway

Journal of Cellular Physiology, 2011
AbstractThe Ras‐ERK/MAP (Mitogen‐Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras‐ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis.
Jarrett T, Whelan, Sarah E, Hollis, Dong Seok, Cha, Adam S, Asch, Myon-Hee, Lee   +4 more
openaire   +2 more sources

Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway

Life Sciences, 2018
Myricetin has been reported to promote osteogenic differentiation and inhibit osteoclastogenesis. The aim of this study was to investigate the potential effects of myricetin on glucocorticoid-induced osteoporosis (GIOP) both in vivo and in vitro. Male Sprague-Dawley (SD) rats were given dexamethasone (DEX, 0.1 mg/kg, s.c.) once daily and myricetin (1 ...
Shuli, Fan, Xiang, Gao, Peng, Chen, Xu, Li   +3 more
openaire   +2 more sources

LINC00707 promotes hepatocellular carcinoma progression through activating ERK/JNK/AKT pathway signaling pathway

Journal of Cellular Physiology, 2018
AbstractIncreasing evidence has demonstrated that abnormal expression of lncRNA is correlated with various malignant tumors, including hepatocellular carcinoma (HCC). Our current study was aimed to investigate the role of LINC00707 in HCC development.
Jianchu Wang, Zongjiang Luo, Tianwei Yao, Wenchuan Li, Jian Pu   +4 more
openaire   +2 more sources

HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway

Biology of Reproduction
Abstract Objective The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth. Methods We employed the Cre-loxP recombination system to establish a placenta-
Ming-Rui, Li, En-Xiang, Chen, Zhuo-Hang, Li, Hong-Lan, Song, Yi, Zhang, Fang-Fang, Li, You-Long, Xie, Jing, Tang, Yu-Bin, Ding, Li-Juan, Fu   +9 more
openaire   +2 more sources

ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway

International Immunopharmacology, 2019
Many studies confirmed that the over-activation of RAF-MEK-ERK signaling pathway plays a central role in human cancers. To avoid drug resistance during cancer treatment, many researchers focused on the study of the downstream therapeutic target of RAF-MEK-ERK signaling pathway. Therefore, ERK1/2 became a hot anticancer target.
Xiaoling Huang, Pengxia Yu, Minyu Liu, Yifang Deng, Yuqiong Dong, Quanhai Liu, Jintao Zhang, Tong Wu   +7 more
openaire   +2 more sources

Deciphering Signaling Pathways In Vivo: The Ras/Raf/Mek/Erk Cascade

2010
The Ras/Raf/MEK/ERK cascade is a highly conserved signal transduction module, whose activation results in a number of different physiological outcomes. Depending on the cell type or the stimulus used, the pathway has been implicated in proliferation, differentiation, apoptosis, and migration.
Galabova-Kovacs, Gergana, Baccarini, Manuela   +1 more
openaire   +3 more sources

ERK signaling pathway involvement in free mitochondria transfer

Mitochondria play an important role in metabolism, and their primary function is aerobic respiration and the creation of ATP to meet the energy needs important for cell survival. Mitochondrial dysfunction plays a key role in a wide range of diseases including tumors.
Suman, Iva, Grčić, Antonijo, Budeš, Ana-Marija, Šimić, Lidija, Višnić, Alenka, Domitrović, Robert   +5 more
openaire