Results 101 to 110 of about 53,817 (192)

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Jonathan Cunningham
wiley   +1 more source

Synthese Unkonventioneller α‐Polyhalogenierter Amine Durch Hydroaminoalkylierung

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Es wird ein redox‐neutrales Verfahren beschrieben, bei dem Alkene und Alkine unter Verwendung stabiler Hemiaminal‐Reagenzien in α‐Polyhalogenmethylamine umgewandelt werden. Dieser Ansatz ermöglicht den Zugang zu α‐CF3‐, α‐CF2H‐, α‐CF2Cl‐, und α‐CFClH‐Aminen und besticht durch ein breites Substratspektrum, eine hohe Toleranz gegenüber funktionellen ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

Phase I/II Trial of Cetuximab and Erlotinib in Patients with Lung Adenocarcinoma and Acquired Resistance to Erlotinib

, 2011
Purpose: In patients with epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma, treatment with erlotinib or gefitinib is associated with a 75% radiographic response rate and progression-free survival of approximately 12 months.
Christopher G. Azzoli, Naiyer A. Rizvi, Michelle S. Ginsberg, M Catherine Pietanza, William Pao, Vincent A. Miller, Gregory J. Riely, Lee M. Krug, Leanne K. Pereira, Mark G. Kris, Yelena Y. Janjigian   +10 more
core   +1 more source

Bilateral anterior uveitis secondary to erlotinib [PDF]

, 2010
We would like to report the first case of bilateral severe anterior uveitis secondary to erlotinib. Erlotinib is an epidermal growth factor receptor (EGFR) inhibitor which can contain certain cancer cells [1].
Abdul, Hanifudin, Chee, Peng Cheng, Blum, Robert Alexander, Lim, Lik Thai   +3 more
core   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

The frequency of EGFR And KRAS mutations in the Turkish population with non-small cell lung cancer and their response to erlotinib therapy

Balkan Journal of Medical Genetics, 2018
In this study, profiles of epidermal growth factor receptor (EGFR) and Kirsten ras sarcoma (KRAS) mutations and response to erlotinib therapy have been investigated in patients with non-small cell lung cancer (NSCLC). DNA from 300 patients with NSCLC was
Demiray A, Yaren A, Karagenç N, Bir F, Demiray AG, Karagür ER, Tokgün O, Elmas L, Akça H   +8 more
doaj   +1 more source

Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small-cell lung cancer treatment - case report

BMC Cancer, 2010
Background Stereotactic body radiation therapy (SBRT) applied by helical tomotherapy (HT) is feasible for lung cancer in clinical. Using SBRT concurrently with erlotinib for non-small cell lung cancer (NSCLC) is not reported previously. Case Presentation
Chen Chien-An, Hsieh Yen-Ping, Wang Li-Ying, Chen Yu-Jen, Lin Shih-Chiang, Chang Hou-Tai, Hsieh Chen-Hsi, Chong Ngot-Swan, Lin Shoei, Chen Chun-Yi, Shueng Pei-Wei   +10 more
doaj   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

Angewandte Chemie International Edition, Volume 65, Issue 38, 14 September 2026.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

Erlotinib and patterns of pharmacogenomic (PGx) testing.

, 2012
182 Background: Erlotinib is an oral oncology drug that costs approximately $5,000 per month. Both the NCCN Guidelines (since March 2011) and ASCO (since April 2011) recommend PGx testing for tumor epidermal growth factor receptor (EGFR) mutation in ...
Yang P. Qiu, Jonas A. De Souza, Catherine I. Starner, Patrick P. Gleason   +3 more
core   +1 more source

Exosomal Transfer of lncRNA H19 Promotes Erlotinib Resistance in Non-Small Cell Lung Cancer via miR-615-3p/ATG7 Axis

Cancer Management and Research, 2020
Rongtao Pan,1 Haiyan Zhou2 1Department of Oncology, Taishan Hospital of Shandong Province, Taian 271000, Shandong, People’s Republic of China; 2Department of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical ...
Pan R, Zhou H
doaj