Results 31 to 40 of about 9,053 (223)
A Robust Prognostic Gene Signature Based on eRNAs-Driven Genes in Prostate Cancer
Frontiers in Genetics, 2021 Prostate cancer (PCa) is the second most common malignancy in men, but its exact pathogenetic mechanisms remain unclear. This study explores the effect of enhancer RNAs (eRNAs) in PCa.
Shuaishuai Fan +7 more
doaj +1 more source
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, EarlyView.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source
Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease
Nature CommunicationsDeep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy.
Leon A. Steiner +16 more
doaj +1 more source
A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj +1 more source
THE TRANSFORMATION OF MAJAPAHIT TEMPLE ORNAMENTS INTO BATIK MOTIFS
Artistic, 2022 Batik ERNA Mojokerto is a hand-written Mojokerto-style batik renowned for incorporating a Majapahit theme into its batik production. Some of the names of the batik motifs, such as the Surya Majapahit, Alas Majapahit, and Bunga Cinta Majapahit, have ...
Ken Andhisti
doaj +1 more source
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms
Nature Communications, 2023 The extracellular matrix of bacterial biofilms consists of diverse components including polysaccharides, proteins and DNA. Extracellular RNA (eRNA) can also be present, contributing to the structural integrity of biofilms. However, technical difficulties
Sudarsan Mugunthan +13 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Deep brain stimulation (DBS) targeted to the globus pallidus (GP) can effectively alleviate dystonia symptoms. However, identifying optimal therapeutic stimulation parameters is challenging due to the manual programming process and the paucity of acute effects of DBS on dystonia symptoms.
Kara A. Johnson +7 more
wiley +1 more source
Finding Maximum Weight 2‐Packing Sets on Arbitrary Graphs
Networks, EarlyView.ABSTRACT A 2‐packing set for an undirected, weighted graph G=(V,E,w)$$ G=\left(V,\kern0.3em E,\kern0.3em w\right) $$ is a subset 𝒮⊆V such that any two vertices v1,v2∈𝒮 are not adjacent and have no common neighbors. The Maximum Weight 2‐Packing Set problem that asks for a 2‐packing set of maximum weight is NP$$ \mathbf{NP} $$‐hard. Next to 13 novel data
Jannick Borowitz +2 more
wiley +1 more source
Capacity building needed to reap the benefits of access to biodiversity collections
PLANTS, PEOPLE, PLANET, EarlyView.Global conservation efforts increasingly depend on digitised natural history collections, yet the benefits of this digital data are not equally shared. We analysed biodiversity specimens and citation data from Montserrat and the Cayman Islands to assess who collected these specimens, how they are used, and by whom.
Quentin Groom +16 more
wiley +1 more source