Results 1 to 10 of about 308,170 (153)

An enhancer RNA recruits KMT2A to regulate transcription of Myb [PDF]

Cell Reports
Summary: The Myb proto-oncogene encodes the transcription factor c-MYB, which is critical for hematopoiesis. Distant enhancers of Myb form a hub of interactions with the Myb promoter.
Juhyun Kim, Ivan Krivega, Ann Dean
exaly   +4 more sources

Identification of cell states using super-enhancer RNA [PDF]

BMC Genomics, 2021
Background A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease states.
Yueh-Hua Tu, Hsueh-Fen Juan, Hsuan-Cheng Huang   +2 more
doaj   +2 more sources

Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases [PDF]

Biomedicines
Cardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies are urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer new directions for the treatment of ...
Yi He, Yuwei Cai, Yanyan Cao, Yan Wang, Jing Wang, Hu Ding   +5 more
doaj   +2 more sources

Enhancer-Derived RNA: A Primer

Genomics, Proteomics and Bioinformatics, 2017
Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome.
Feng Liu
exaly   +3 more sources

Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide [PDF]

Cell Death and Disease
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear.
Tengfei Shi, Dianhao Guo, Yaoqiang Zheng, Wenbin Wang, Jinfang Bi, Anshun He, Sibo Fan, Guangsong Su, Xueyuan Zhao, Zhenhao Zhao, Yingjie Song, Shupeng Sun, Peng Li, Zhongfang Zhao, Jiandang Shi, Wange Lu, Lei Zhang   +16 more
doaj   +2 more sources

Enhancer RNA (eRNA) in Human Diseases [PDF]

International Journal of Molecular Sciences, 2022
Yunzhe Wang, Yuxiang Wang, Xiuping Liu   +2 more
exaly   +2 more sources

GAS1RR, an immune-related enhancer RNA, is related to biochemical recurrence-free survival in prostate cancer [PDF]

Experimental Biology and Medicine, 2023
Ze Zhong Xiong
exaly   +2 more sources

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation [PDF]

Molecular Cell, 2021
Joo-Hyung Lee, Ruoyu Wang, Feng Xiong
exaly   +2 more sources

Development and Validation of a Novel Prognostic Model for Lower-Grade Glioma Based on Enhancer RNA-Regulated Prognostic Genes

Frontiers in Oncology, 2022
Enhancer RNAs (eRNAs) are present specifically in tumors, where they affect the expression of eRNA-regulated genes (ERGs). Owing to this characteristic, ERGs were hypothesized to improve prognosis of overall survival in heterogeneous low-grade and ...
Wei Tian, Guangcan Yan, Kegong Chen, Xinhao Han, Wei Zhang, Lin Sun, Qi Zhang, Yafeng Zhang, Yan Li, Meina Liu, Qiuju Zhang   +10 more
doaj   +1 more source

selSeq: A method for the enrichment of non-polyadenylated RNAs including enhancer and long non-coding RNAs for sequencing.

PLoS ONE, 2023
Non-polyadenylated RNA includes a large subset of crucial regulators of RNA expression and constitutes a substantial portion of the transcriptome, playing essential roles in gene regulation.
Jason D Limberis, Alina Nalyvayko, Joel D Ernst, John Z Metcalfe   +3 more
doaj   +1 more source