Enhancer RNAs: Insights Into Their Biological Role [PDF]
Epigenetics Insights, 2019 Enhancers play a central role in the transcriptional regulation of metazoans. Almost a decade ago, the discovery of their pervasive transcription into noncoding RNAs, termed enhancer RNAs (eRNAs), opened a whole new field of study. The presence of eRNAs correlates with enhancer activity; however, whether they act as functional molecules remains ...
de Lara, Josué Cortés-Fernández +2 more
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Landscape of Enhancer-Enhancer Cooperative Regulation during Human Cardiac Commitment
Molecular Therapy: Nucleic Acids, 2019 Although accumulating evidence has demonstrated the key roles of enhancers in gene expression regulation, the contribution of genome-wide enhancer-enhancer interactions to developmental decisions remains unclear.
Hong Chen +13 more
doaj +1 more source
The bacterial enhancer-dependent RNA polymerase [PDF]
Biochemical Journal, 2016 Transcription initiation is highly regulated in bacterial cells, allowing adaptive gene regulation in response to environment cues. One class of promoter specificity factor called sigma54 enables such adaptive gene expression through its ability to lock the RNA polymerase down into a state unable to melt out promoter DNA for transcription initiation ...
Zhang, N +4 more
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Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation
Cell Reports, 2021 Summary: Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers.
BongWoo Kim +7 more
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A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. [PDF]
, 2016 Gonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal reproductive development and function ...
Brusman, Liza E +4 more
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Integrator mediates the biogenesis of enhancer RNAs [PDF]
Nature, 2015 Integrator is a multi-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII). Integrator is endowed with a core catalytic RNA endonuclease activity, which is required for the 3'-end processing of non-polyadenylated, RNAPII-dependent, uridylate-rich, small nuclear RNA genes. Here we examine the requirement
Lai, Fan +3 more
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Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
Nature Communications, 2020 Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the ...
Katla Kristjánsdóttir +3 more
doaj +1 more source
Tissue-specific RNA expression marks distant-acting developmental enhancers. [PDF]
PLoS Genetics, 2014 Short non-coding transcripts can be transcribed from distant-acting transcriptional enhancer loci, but the prevalence of such enhancer RNAs (eRNAs) within the transcriptome, and the association of eRNA expression with tissue-specific enhancer activity in
Han Wu +7 more
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Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. [PDF]
, 2019 Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands.
Aaron Hardin +65 more
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The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans
Cell Reports, 2017 Summary: Enhancer-derived RNAs are thought to act locally by contributing to their parent enhancer function. Whether large domains of clustered enhancers (super-enhancers) also produce cis-acting RNAs, however, remains unclear.
Juan R. Alvarez-Dominguez +3 more
doaj +1 more source