Results 131 to 140 of about 2,468,151 (278)
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source
Advanced Science, EarlyView.A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee +9 more
wiley +1 more source
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang +15 more
wiley +1 more source
Shuitu baochi yanjiuObjectiveThis study aims to evaluate the priority levels of soil erosion control in small watersheds of Luonan County， Shaanxi Province， to provide a theoretical basis and decision-making support for targeted， scientific， and efficient regional soil and ...
Zhu Xiangjun +5 more
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Advanced Science, EarlyView.Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok +13 more
wiley +1 more source
REDES 2.0: A pan-European rainfall erosivity dataset showing intensifying erosivity trends
oai:publications.jrc.ec.europa.eu:JRC146004Rainfall erosivity (defined as R-factor of the Revised Universal Soil Loss equation (RUSLE)), a key driver of soil erosion by water, varies greatly across Europe due to differences in climate regimes ...
LIAKOS Leonidas +23 more
core +1 more source
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
Radar remote sensing reveals potential underestimation of rainfall erosivity at the global scale. [PDF]
Sci Adv, 2023 Dai Q +6 more
europepmc +1 more source
Rainfall erosivity attributes on central and western Mauritius [PDF]
, 2013 Dissertation (MSc)--University of Pretoria, 2012.Rainfall can be the most erosive agent with respect to rainfall induced erosion, particularly within the context of a tropical maritime environment.
core