Results 91 to 100 of about 2,420,035 (290)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Fourier Spectral Methods for Some Linear Stochastic Space-Fractional Partial Differential Equations
Mathematics, 2016 Fourier spectral methods for solving some linear stochastic space-fractional partial differential equations perturbed by space-time white noises in the one-dimensional case are introduced and analysed.
Yanmei Liu, Monzorul Khan, Yubin Yan
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
On a posteriori error estimates [PDF]
Mathematics of Computation, 1977 Consider a sequence { x n } n = 0 ∞ \{ {x_n}\} _{n = 0}^\infty in a normed space X converging to some x ∗ ∈ X ...
openaire +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Uniform Error Estimates of the Finite Element Method for the Navier-Stokes Equations in R2 with L2 Initial Data. [PDF]
Entropy (Basel), 2023 Ren S, Wang K, Feng X.
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Error estimates and physics informed augmentation of neural networks for thermally coupled incompressible Navier Stokes equations. [PDF]
Comput Mech, 2023 Goraya S, Sobh N, Masud A.
europepmc +1 more source
On calculating estimates of stratified error-components models [PDF]
This note provides an AECM (alternating expectation conditional maximization) algorithm for calculating maximum-likelihood estimates of stratified error-components models.
Robert Phillips
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source