Results 111 to 120 of about 2,420,035 (290)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
MathematicsIn this paper, we present a compact finite difference method for solving the cubic–quintic Schrödinger equation with an additional anti-cubic nonlinearity.
He Yang
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
A nonhomogeneous backward heat problem: Regularization and error estimates
Electronic Journal of Differential Equations, 2008 We consider the problem of finding the initial temperature, from the final temperature, in the nonhomogeneous heat equation $$displaylines{ u_t-u_{xx}= f(x,t),quad (x,t)in (0,pi)imes (0,T),\ u(0,t)= u(pi,t)= 0, quad (x,t) in (0,pi)imes(0,T ...
Trong Dang Duc, Huy Tuan Nguyen
doaj
Novel Numerical Investigation of Reaction Diffusion Equation Arising in Oil Price Modeling
MathematicsConsideration is given to a reaction–diffusion free boundary value problem with one or two turning points arising in oil price modeling. First, an exact (analytical) solution to the reduced problem (i.e., no diffusion term) was obtained for some given ...
Fehaid Salem Alshammari
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Mathematical and Computer Modelling of Dynamical SystemsThis paper presents an energy stable scheme for the numerical solution of the Allen–Cahn equation. The scheme combines the Crank–Nicolson/Adams–Bashforth technique with the Galerkin method, complementing a thoughtfully designed stabilization term.
Panason Manorot +2 more
doaj +1 more source