Results 81 to 90 of about 3,775,327 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cluster robust error estimates for the Rayleigh-Ritz approximation II: Estimates for eigenvalues

, 2005
This is the second part of a paper that deals with error estimates for the Rayleigh–Ritz approximations of the spectrum and invariant subspaces of a bounded Hermitian operator in a Hilbert or Euclidean space.
E. Ovtchinnikov, Ovtchinnikov, E.
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimal and Pressure-Independent $$L^2$$ L 2 Velocity Error Estimates for a Modified Crouzeix-Raviart Element with BDM Reconstructions

, 2014
Nearly all inf-sup stable mixed finite elements for the incompressible Stokes equations relax the divergence constraint. The price to pay is that a-priori estimates for the velocity error become pressure-dependent, while divergence-free mixed finite ...
Christian Brennecke, Linke, Alexander, Merdon, Christian, Schöberl, Joachim, Brennecke, Christian, Alexander Linke, Joachim Schöberl, Christian Merdon   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Consumer Surplus Estimates and the Source of Regression Error [PDF]

Contrary to widely held belief, we show that the source of regression error does not matter when calculating Marshallian surplus. A misspecified demand curve, not the assumed source of regression error, leads to differences in estimates of consumer ...
Beatty, Timothy K.M., Ward, Michael B., Brozovic, Nicholas   +2 more
core  

Measurement error in time-series analysis: a simulation study comparing modelled and monitored data. [PDF]

, 2013
BACKGROUND: Assessing health effects from background exposure to air pollution is often hampered by the sparseness of pollution monitoring networks. However, regional atmospheric chemistry-transport models (CTMs) can provide pollution data with national ...
Richard W Atkinson, Doherty, Ruth M., Butland, BK, Massimo Vieno, Ruth M Doherty, Doherty, Ruth M, Ben Armstrong, Doherty, RM, Heal, Mathew R, Heal, MR, Paul Wilkinson, Vieno, Massimo, Armstrong, Ben, Atkinson, Richard W., Heal, Mathew R., Vieno, M, Mathew R Heal, Butland, Barbara K, Wilkinson, Paul, Armstrong, B, Atkinson, RW, Atkinson, Richard W, Butland, Barbara K., Barbara K Butland, Wilkinson, P, Heal, Mathew R; id_orcid   +25 more
core   +3 more sources

Chebyshev’s Method for Multiple Zeros of Analytic Functions: Convergence, Dynamics and Real-World Applications

Mathematics
This paper deals with the convergence and dynamics of Chebyshev’s method for simple and multiple zeros of analytic functions. We establish a local convergence theorem that provides error estimates and exact domains of initial approximations to guarantee ...
Stoyanka G. Kostadinova, Stoil I. Ivanov
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source