Results 31 to 40 of about 1,666,189 (240)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Analysis of Adjoint Error Correction for Superconvergent Functional Estimates [PDF]

, 2001
Earlier work introduced the notion of adjoint error correction for obtaining superconvergent estimates of functional outputs from approximate PDE solutions. This idea is based on a posteriori error analysis suggesting that the leading order error term in
Giles, M. B., Pierce, Niles A.
core  

In-Pipeline Processor Protection against Soft Errors

Journal of Low Power Electronics and Applications, 2023
The shrinking of technology nodes allows higher performance, but susceptibility to soft errors increases. The protection has been implemented mainly by lockstep or hardened process techniques, which results in a lower frequency, a larger area, and higher
Ján Mach, Lukáš Kohútka, Pavel Čičák   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

On a Method for Constructing Optimal Difference Formulas Using Discrete Operators with Variable Coefficients

Algorithms
This paper deals with the problem of constructing optimal difference formulas in the Hilbert space H2m0,1 through Sobolev’s method. Firstly, Sobolev’s method of construction of optimal difference formulas in the Hilbert space H2m0,1, which is based on ...
Kholmat Shadimetov, Shermamat Esanov
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Seeking for reliable double-hybrid density functionals without fitting parameters: The PBE0-2 functional

, 2012
Without the use of any empirical fitting to experimental or high-level ab initio data, we present a double-hybrid density functional approximation for the exchange-correlation energy, combining the exact Hartree-Fock exchange and second-order Moller ...
Adamo, Bally, Becke, Boys, Brémond, Burns, Chai, Chai, Chai, Chai, Cohen, Curtiss, Curtiss, Curtiss, Dion, Dirac, Dobson, Grimme, Grimme, Grimme, Grimme, Grimme, Jeng-Da Chai, Jurečka, Kendall, Kohn, Kurlancheek, Mller, Perdew, Perdew, Perdew, Perdew, Pople, Raghavachari, Redfern, Rezac, Shan-Ping Mao, Shao, Sharkas, Song, Steinmann, Stephens, Takatani, Tao, Toulouse, Wodrich, Zhang, Zhao, Zhao, Zhao, Zhao   +50 more
core   +1 more source

HURST EXPONENT ESTIMATES ON SMALL SAMPLES: THE SIMPLEST VERSION OF FEDER'S NON-LINEAR METHOD ERROR COMPENSATOR FOR MODELING ECONOMIC AND BIOMETRIC DATA

Надежность и качество сложных систем, 2023
Background. Currently, the Hurst exponent is quite easily interpreted in relation to biometric, medical and economic data, but it is customary to evaluate it on large samples.
Aleksandr I. Ivanov, Dmitriy V. Tarasov, Kirill A. Gorbunov   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source