Results 51 to 60 of about 1,049,459 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Functional a posteriori Error Estimates for Time-periodic Parabolic Optimal Control Problems
, 2016 This article is devoted to the a posteriori error analysis of multiharmonic finite element approximations to distributed optimal control problems with time-periodic state equations of parabolic type.
Wolfmayr, Monika +2 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Optimal quadrature formulas for approximate calculation of rapidly oscillating integrals
Results in Applied MathematicsIn this paper, we study the problem of constructing optimal formulas for approximate integration in the Sobolev space L2m˜0,1 of periodic functions. Using the functional approach, we obtain optimal quadrature formulas for the approximate calculation of ...
Kholmat Shadimetov +2 more
doaj +1 more source
General aspects of Trefftz method and relations to error estimation of finite element approximations
Computer Assisted Methods in Engineering and Science, 2023 In this paper a guaranteed upper bound of the global discretization error in linear elastic finite element approximations is presented, based on a generalized Trefftz functional. Therefore, the general concept of complementary energy functionals and the
Stephan Ohnimus +2 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Dysfunctional Curriculum: creating the battles against capitalism
Educação & Realidade, 2018 Starting on the premise of a functional Capitalism that is not afraid of rejecting its own ideas to reassure itself as an overcoding machine, this essay points to the curricular practices in the production of pauses based on a philosophy of error. If, in
Steferson Zanoni Roseiro +1 more
doaj +1 more source
Functional network activity during errorless and trial‐and‐error color‐name association learning
Brain and Behavior, 2020 Introduction In cognitive rehabilitation, errorless (EL) and trial‐and‐error (T&E) learning are well‐known methods, but their neural mechanisms are not well known.
Madoka Yamashita +3 more
doaj +1 more source
Short-Term Drift Prediction of Multi-Functional Buoys in Inland Rivers Based on Deep Learning
Sensors, 2022 The multi-functional buoy is an important facility for assisting the navigation of inland waterway ships. Therefore, real-time tracking of its position is an essential process to ensure the safety of ship navigation.
Fei Zeng, Hongri Ou, Qing Wu
doaj +1 more source
, 2022 Error-based learning is one of the basic skill acquisition mechanisms that can be modeled as a perception–action system and investigated based on brain–behavior analysis during skill training.
Steven D. Schwaitzberg (17682513) +7 more
core +1 more source