Results 61 to 70 of about 2,660,340 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Putting error bars on density functional theory

Scientific Reports
Predicting the error in density functional theory (DFT) calculations due to the choice of exchange–correlation (XC) functional is crucial to the success of DFT, but currently, there are limited options to estimate this a priori.
Simuck F. Yuk, Irmak Sargin, Noah Meyer, Jaron T. Krogel, Scott P. Beckman, Valentino R. Cooper   +5 more
doaj   +1 more source

Nonparametric Functional Least Absolute Relative Error Regression: Application to Econophysics

Mathematics
In this paper, we propose an alternative kernel estimator for the regression operator of scalar response variable S given a functional random variable T that takes values in a semi-metric space.
Ali Laksaci, Ibrahim M. Almanjahie, Mustapha Rachdi   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Scalar-on-Function Regression with Replicated Error-Prone Functional Covariates

Mathematics
In this article, we study scalar-on-function regression with functional covariates observed through replicated measurements subject to measurement error.
Xiyue Cao, Chunzheng Cao
doaj   +1 more source

Enumerating Counter-Factual Type Error Messages with an Existing Type Checker [PDF]

, 2014
The type error message of a standard type checker for a functional language gives only a single location as potential cause of the type error. If that location is not the cause, which often is the case, then the type error message hardly helps in ...
Chitil, Olaf, Tsushima, Kanae
core   +1 more source

A Posteriori Error Control for the Binary Mumford-Shah Model

, 2015
The binary Mumford-Shah model is a widespread tool for image segmentation and can be considered as a basic model in shape optimization with a broad range of applications in computer vision, ranging from basic segmentation and labeling to object ...
Berkels, Benjamin, Effland, Alexander, Rumpf, Martin   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bayesian Error Estimation in Density-Functional Theory [PDF]

Physical Review Letters, 2005
We present a practical scheme for performing error estimates for Density Functional Theory calculations. The approach which is based on ideas from Bayesian statistics involves creating an ensemble of exchange-correlation functionals by comparing with an experimental database of binding energies for molecules and solids. Fluctuations within the ensemble
Mortensen, Jens Jørgen, Kaasbjerg, Kristen, Frederiksen, Søren Lund, Nørskov, Jens Kehlet, Sethna, J.P., Jacobsen, Karsten Wedel   +5 more
openaire   +4 more sources

Coulomb exchange functional with generalized gradient approximation for self-consistent Skyrme Hartree-Fock calculations

, 2019
We perform the self-consistent Skyrme Hartree-Fock calculation with the Coulomb exchange functional in the form of generalized gradient approximation (GGA).
Colò, Gianluca, Liang, Haozhao, Naito, Tomoya, Roca-Maza, Xavier   +3 more
core   +1 more source