Results 41 to 50 of about 814,507 (284)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Paradox of Precision

open access: yesOrbital: The Electronic Journal of Chemistry, 2020
This paper is about a typical mistake in the calculation of standard deviation of measurements in cases in which there are no differences among repetitious replicates. Some students believe the standard deviation in those case is equal to zero.
André F. Oliveira   +3 more
doaj  

Error propagation in geochemical modeling of trace elements in two-component mixing [PDF]

open access: yesGeofísica Internacional, 1998
This study presents error propagation equations for geochemical modeling of trace elements during mixing of two components or end-members. These equations can be used to estimate uncertainties in the concentration of an element or ratio of two elements ...
Surendra P. Verma
doaj  

Hybrid SGP4 orbit propagator

open access: yes, 2017
Two-Line Elements (TLEs) continue to be the sole public source of orbiter observations. The accuracy of TLE propagations through the Simplified General Perturbations-4 (SGP4) software decreases dramatically as the propagation horizon increases, and thus ...
Pérez, Iván   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

An Effective Fanout-Based Method for Improving Error Propagation Probability Estimation in Combinational Circuits

open access: yesIEEE Access
The downsizing of nanoscale circuits imposes new challenges for circuit reliability, including hard defects, soft errors and unsaturated voltage/current.
Esfandiar Esmaieli   +2 more
doaj   +1 more source

Índices de capacidade de relações funcionais lineares e não-lineares Capability index for linear and non-linear functions

open access: yesProduction, 2004
São apresentados métodos para determinação dos índices de capacidade tais como Cp e Cpk aplicados no "design for six sigma" (DFSS) quando a característica de qualidade é não-observável e dada por Y = f(X1, X2, X3,....Xk), onde Xi são variáveis aleatórias
Edivaldo Antonio Bulba, Linda Lee Ho
doaj   +1 more source

A theory of human error [PDF]

open access: yes, 1981
Human errors tend to be treated in terms of clinical and anecdotal descriptions, from which remedial measures are difficult to derive. Correction of the sources of human error requires an attempt to reconstruct underlying and contributing causes of error
Allen, R. W.   +2 more
core   +1 more source

Reliable random error estimation in the measurement of line-strength indices [PDF]

open access: yes, 1997
We present a new set of accurate formulae for the computation of random errors in the measurement of atomic and molecular indices. The new expressions are in excellent agreement with numerical simulations.
Cardiel, N.   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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