Results 71 to 80 of about 18,518,960 (329)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Optimization of False Alarm Rate and Misdetection Rate for a Desired Threshold Voltage in Cooperative Communication

Jordanian Journal of Computers and Information Technology
Cooperative communication system (CCS) involves collaboration among sensor nodes to transmit data more effectively, especially in scenarios with limited resources or challenging environmental conditions.
SATISH KUMAR GANNAMANENI, JIBENDU SEKHAR ROY   +1 more
doaj   +1 more source

Stabilizing minimum error rate training [PDF]

Proceedings of the Fourth Workshop on Statistical Machine Translation - StatMT '09, 2009
The most commonly used method for training feature weights in statistical machine translation (SMT) systems is Och's minimum error rate training (MERT) procedure. A well-known problem with Och's procedure is that it tends to be sensitive to small changes in the system, particularly when the number of features is large.
Foster, George, Kuhn, Roland
openaire   +2 more sources

Deep Belief Network Training Improvement Using Elite Samples Minimizing Free Energy

, 2014
Nowadays this is very popular to use deep architectures in machine learning. Deep Belief Networks (DBNs) are deep architectures that use stack of Restricted Boltzmann Machines (RBM) to create a powerful generative model using training data. In this paper
Homayounpour, Mohammad Mehdi, Keyvanrad, Mohammad Ali   +1 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

An attempt of finding an appropriate number of convolutional layers in cnns based on benchmarks of heterogeneous datasets

Electrical, Control and Communication Engineering, 2018
An attempt of finding an appropriate number of convolutional layers in convolutional neural networks is made. The benchmark datasets are CIFAR-10, NORB and EEACL26, whose diversity and heterogeneousness must serve for a general applicability of a rule ...
Romanuke Vadim V.
doaj   +1 more source

Assessment of Drugs Toxicity and Associated Biomarker Genes Using Hierarchical Clustering

Medicina, 2019
Background and objectives: Assessment of drugs toxicity and associated biomarker genes is one of the most important tasks in the pre-clinical phase of drug development pipeline as well as in toxicogenomic studies.
Mohammad Nazmol Hasan, Masuma Binte Malek, Anjuman Ara Begum, Moizur Rahman, Md. Nurul Haque Mollah   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Improving the objective function in minimum error rate training [PDF]

, 2009
In Minimum Error Rate Training (MERT), the parameters of an SMT system are tuned on a certain evaluation metric to improve translation quality. In this paper, we present empirical results in which parameters tuned on one metric (e.g.
He, Yifan, Way, Andy
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source