Results 121 to 130 of about 107,750 (302)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Diagnostic parallels between borderline and bipolar patients in psychopathology: Similarities, differences, comorbidities, neural correlates, and a new proposal for the Perrotta Border‐Bipolar Profile Diagnostic Questionnaire

Ibrain
In psychopathology, one of the most complex challenges is offered by the diagnostic comparison between patients with borderline personality disorder and those with bipolar spectrum disorder, as some of the symptoms characterizing the two disorders ...
Giulio Perrotta, Simona Grilli, Stefano Eleuteri, Irene Petruccelli   +3 more
doaj   +1 more source

Eye Movement Metrics in the Differentiation of Parkinsonian Syndromes. [PDF]

, 2017
Eye Movement Metrics in the Differentiation of Parkinsonian Syndromes Cecilia Bonnet, MD Summary of thesis submitted for the degree of Ph.D., Charles University, Prague 2017 In this thesis we investigated conjugate and dis-conjugate eye movements (EM) in
Bonnet, Cecilia
core  

qecGPT: decoding Quantum Error-correcting Codes with Generative Pre-trained Transformers

, 2023
We propose a general framework for decoding quantum error-correcting codes with generative modeling. The model utilizes autoregressive neural networks, specifically Transformers, to learn the joint probability of logical operators and syndromes.
Zhang, Pan, Pan, Feng, Wang, Yijia, Cao, Hanyan   +3 more
core  

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Case report: A germline CHEK1 c.613 + 2T>C leads to a splicing error in a family with multiple cancer patients

Frontiers in Oncology
BackgroundGenome instability plays a crucial role in promoting tumor development. Germline mutations in genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene.
Jun Qian, Min Peng, Yanan Li, Wei Liu, Xinwei Zou, Huafei Chen, Sujuan Zhou, Sheng Xiao, Jinhua Zhou   +8 more
doaj   +1 more source

Multiple Description Distributed Video Coding Using Redundant Slices and Lossy Syndromes

, 2010
During the last years, video coding designers have proposed robust coding approaches that combine Multiple Description Coding (MDC) schemes with Distributed Video Coding (DVC) principles.
MILANI, SIMONE, CALVAGNO, GIANCARLO
core   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Relationships between radiation-induced survivorship syndromes and frequency of citrus intake.

, 2019
The figure depicts the relationships between frequency of citrus intake (x-axis) and intensities (factor scores) of the five radiation induced syndromes (y-axis: defecation-urgency syndrome, fecal-leakage syndrome, excessive gas discharge, excessive ...
Viktor Skokic (3716413), Ulrica Wilderäng (835905), Cecilia Bull (3716410), Fei Sjöberg (3716416), Gunnar Steineck (226792), Maria Hedelin (6169583), Gail Dunberger (2743204), Rebecca Ahlin (6169586), Karin Bergmark (3716422), Andrea Stringer (6169589)   +9 more
core   +1 more source