Results 141 to 150 of about 72,397 (309)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2009 Este OA muestra todas las herramientas disponibles para limpiar una cartografía, corregir errores dangle, pseudonodos y generar la topología para poder trabajar de forma correcta en el análisis de los datos geográficos.https://polimedia.upv.es/visor ...
Coll-Aliaga, Eloína
core
, 2020 The quality of the radiographic image is essential for the diagnosis and conservation of x-rays in archive. However, there are some Dental specialties that, for force of the ...
Cuadros Rodríguez , Cristhian Paúl
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Percepción de la seguridad del paciente en odontología Perceptions of patient safety in dentistry
Revista de la Asociación Odontológica Argentina, 2015 Resumen Objetivo: Identificar los factores de riesgo relacionados con la seguridad del paciente en la práctica odontológica. Materiales y métodos: Se realizó un estudio observacional, descriptivo, utilizando un cuestionario para conocer el grado de
Juan José Christiani +1 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Impacto en las PIMES de las políticas contables.
Perspectivas, 2018 En tiempos recientes ha cobrado singular importancia la tendencia hacia la desregulación de las relaciones comerciales, el fortalecimiento de las instituciones financieras, la diversificación de los mercados, el uso de la transferencia electrónica de ...
Gustavo Caro Vargas
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Normas de calidad, errores accidentales y errores sistemáticos en los niveles automáticos
, 2004 Hace tiempo se estudiaban los errores accidentales (errores aleatorios producidos por la falta de apreciación del observador y sensibilidad del nivel) y los errores sistemáticos (producidos por falta de reglaje en el instrumento y que se distribuyen ...
Cruz González, José Luis de la
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source