Results 121 to 130 of about 72,397 (309)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2008 Procedimiento para la determinación del error asociado a un resultado a partir de los errores de los datos de partida.https://polimedia.upv.es/visor/?id=804672fe-928f-7f42-9ea1-c83ed074f0e3Giménez Valentín, MH. (2008). Propagación de Errores.
Gimenez Valentin, Marcos Herminio +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2013 Introducción: El uso racional de los medicamentos se ha convertido en los últimos años en una materia pendiente sustancial para la práctica médica.
Morales, Sergio Daniel +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Engraved plate with 2 symbolic orbs surmounted by crosses.Signatures: A-F¹² G⁶.Title page vignette.By J.V. Andrea; cf. Faber du Faur.Faber du Faur,Hogart, R.
Andreä, Johann Valentin, 1586-1654.
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Errores en geometría: clasificación e incidencia en un curso preuniversitario
Revista Iberoamericana de Educación, 2010 Los estudiantes de Ingeniería Agronómica, y también los ingenieros agrónomos, en muchas situaciones diarias, tienen necesidad del reconocimiento de formas, relaciones o estructuras, en definitiva del uso de la geometría.
Mónica Bocco, Claudina Canter
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source