Results 101 to 110 of about 101,764 (301)
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Evaluación y aprendizaje [PDF]
La evaluación formativa o evaluación para aprender, la evaluación como elemento esencial de todo el proceso de aprendizaje es el objetivo de este trabajo. Sin menoscabo de otros tipos de evaluación y de la fecunda reflexión sobre creación y corrección de
Fernández, Sonsoles
doaj
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Manejo de glucómetros: detección de errores e intervención farmacéutica
INTRODUCCIÓN La técnica de automonitorización de la glucemia en sangre capilar (AMG) es una parte esencial en el control de la diabetes y de sus complicaciones.
Santiago Puchol Enguídanos +7 more
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Posibles errores de inexpertos empresarios [PDF]
La presente nota académica tiene como objetivo reflejar los errores que suelen cometer los empresarios sin experiencia y así ayudar a nuestros alumnos a que no cometan esos errores cuando salgan de la universidad y decidan empezar una carrera como ...
Martos Gómez, José Juan
core
Errores médicos: trasfondos [PDF]
Es verdad que algunos errores médicos pueden costarle la vida a un paciente. Es verdad que otros errores pueden causar enorme daño a quien los padece. Pero eso no es inherente al quehacer médico. Eso es inherente al quehacer humano.
Villarreal Menchola, Juan
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source

