Results 111 to 120 of about 101,764 (301)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Errores más frecuentes cometidos en los trabajos de terminación de la especialidad
Medimay, 2014 Se realizó un estudio descriptivo retrospectivo con el objetivo de analizar los errores más frecuentes encontrados en los trabajos de terminación de la especialidad de Medicina General Integral, en el Policlínico Comunitario Güines Norte, municipio ...
Magda Emilia Alonso Cordero +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2015 The article surveys ideas emerging within the predicative tradition in the foundations of mathematics, and attempts a reading of predicativity constraints as highlighting different levels of understanding in mathematics. A connection is made with two kinds of error which appear in mathematics: local and foundational errors. The suggestion is that ideas
openaire +3 more sources
Australasian Journal of Philosophy, 2008 Moral error theory of the kind defended by J. L. Mackie and Richard Joyce is premised on two claims: (1) that moral judgements essentially presuppose that moral value has absolute authority, and (2) that this presupposition is false, because nothing has absolute authority. This paper accepts (2) but rejects (1).
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bol Prev Errores Medicación Cataluña
, 2004 Errors de medicació; Prescripció de medicamentsMedication errors; Drug prescriptionErrores de medicación; Prescripción de medicamentosPrescripció electrònica i errors de medicació / Exemples d'errors notificats relacionats amb la prescripció / Dades ...
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Letras, 2014 Les enseignants de FLE affrontent des difficultés au moment de combiner les courants européens en évaluation et en docimologie, avec les directives du MEP par rapport aux épreuves pour les compétences écrites, spécifiquement dans la rédaction des ...
Jorge Pablo Barth Arroyo
doaj