Results 61 to 70 of about 276,204 (279)

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Underground Leachate Distribution Based on Electrical Resistivity in Piyungan Landfill, Bantul

Indonesian Journal of Geography, 2018
Piyungan Landfill is constructed to accommodate the disposal of wastes from Yogyakarta City, Sleman Regency, and Bantul Regency. Overland flow that passes through landfillsand potentially dissolves organic and anorganic materials in a high concentration ...
Harjito Harjito, Suntoro Suntoro, Totok Gunawan, M. Maskuri   +3 more
doaj   +1 more source

Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document. [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Arngrímsson, Reynir, Barbey, Frederic, Biegstraaten, Marieke, Boks, Lut, Cecchi, Franco, Deegan, Patrick B, Feldt-Rasmussen, Ulla, Geberhiwot, Tarekegn, Germain, Dominique P, Hendriksz, Chris, Hollak, Carla E M, Hughes, Derralynn A, Kantola, Ilkka, Karabul, Nesrin, Lavery, Christine, Linthorst, Gabor E, Mehta, Atul, Oliveira, João P, Parini, Rossella, Ramaswami, Uma, Rudnicki, Michael, Serra, Andreas, Sommer, Claudia, Sunder-Plassmann, Gere, Svarstad, Einar, Sweeb, Annelies, Terryn, Wim, Tylki-Szymanska, Anna, Tøndel, Camilla, van de Mheen, Erica, Vujkovac, Bojan, Weidemann, Frank, Wijburg, Frits A, Woolfson, Peter   +33 more
core   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Geological and geophysical characterization of the Brindisi di Montagna Scalo landslide (Basilicata, Southern Italy)

Geomatics, Natural Hazards & Risk, 2019
The Brindisi di Montagna Scalo Landslide in Southern Italy is an active complex mass movement, which affects the left slope of the Basento River. In the last few decades, this landslide has been continuously monitored, as it directly threatened some of ...
Mario Bentivenga, Alessandro Giocoli, Giuseppe Palladino, Angela Perrone, Sabatino Piscitelli   +4 more
doaj   +1 more source

Aggregation‐Induced Resonance Energy Transfer in Polymer Dots to Boost Electrochemiluminescence Performance for Bioimaging of Glycan on Cells

Advanced Science, EarlyView.
This study pioneers an aggregation‐induced resonance energy transfer mechanism by synergistically integrating aggregation‐induced emission (AIE), resonance energy transfer (RET), and thermally activated delayed fluorescence (TADF) within co‐reactant conjugated polymers to develop self‐enhanced ECL emitters, which achieves an ECL efficiency up to 92.6 ...
Chao Wang, Mengjiao Li, Yiran Li, Xiangfu Hu, Chunlan Li, Ningning Wang, Huangxian Ju   +6 more
wiley   +1 more source

Calibration and Validation of NOAA-21 Ozone Mapping and Profiler Suite (OMPS) Nadir Mapper Sensor Data Record Data

Remote Sensing
The Ozone Mapping and Profiler Suites (OMPS) Nadir Mapper (NM) is a grating spectrometer within the OMPS nadir instruments onboard the SNPP, NOAA-20, and NOAA-21 satellites.
Banghua Yan, Trevor Beck, Junye Chen, Steven Buckner, Xin Jin, Ding Liang, Sirish Uprety, Jingfeng Huang, Lawrence E. Flynn, Likun Wang, Quanhua Liu, Warren D. Porter   +11 more
doaj   +1 more source

Massimo Castri alla Scuola di Ert: un Maestro e il suo metodo

Antropologia e Teatro, 2016
This paper intends to deepen a subject that has not so much explored within the Italian’s performance studies: the pedagogic commitment and the experience as “Actors’ guide” of Massimo Castri.
Vittorio Taboga
doaj   +1 more source

Effectiveness of geocell wall, geogrid and micropile anchors for mitigation of unstable slopes

Geoenvironmental Disasters, 2021
Slope failure mitigation practices are well developed in recent years. Recently, geosynthetic, geocell, and geogrid combined with micropiles are being used extensively in various slope stabilization works. But integrated approaches are still lacking.
Jain Sanjaya Kumar, Mohammed Saleh Nusari, Dangol Purushotam, Acharya Indra Prasad, Shrestha Rajyaswori   +4 more
doaj   +1 more source