Results 21 to 30 of about 4,553 (200)

Cyclin‐Dependent Kinase 1 Inhibition Potentiates the Proliferation of Tonsil‐Derived Mesenchymal Stem Cells by Delaying Cellular Senescence

open access: yesStem Cells International, Volume 2022, Issue 1, 2022., 2022
Mesenchymal stem cells (MSCs) have been widely used in tissue regeneration and stem cell therapy and are currently being tested in numerous clinical trials. Senescence‐related changes in MSC properties have attracted considerable attention. Senescent MSCs exhibit a compromised potential for proliferation; senescence acts as a stress response that ...
Da Hyeon Choi   +3 more
wiley   +1 more source

A closer look at discordant placental echogenicity: two cases under the microscope

open access: yesClinical Case Reports, Volume 9, Issue 7, July 2021., 2021
Discordant placental echogenicity is observed in MC pregnancies complicated with twin anemia‐polycythemia sequence, but could also belong to complicated singleton gestation. Abstract Discordant placental echogenicity is observed in MC pregnancies complicated with twin anemia‐polycythemia sequence, but could also belong to complicated singleton ...
Mariano M. Lanna   +6 more
wiley   +1 more source

Molecular Landscapes and Models of Acute Erythroleukemia

open access: yesHemaSphere, Volume 5, Issue 5, May 2021., 2021
Malignancies of the erythroid lineage are rare but aggressive diseases. Notably, the first insights into their biology emerged over half a century ago from avian and murine tumor viruses‐induced erythroleukemia models providing the rationale for several transgenic mouse models that unraveled the transforming potential of signaling effectors and ...
Alexandre Fagnan   +4 more
wiley   +1 more source

LncRNA NKX2‐1‐AS1 promotes tumor progression and angiogenesis via upregulation of SERPINE1 expression and activation of the VEGFR‐2 signaling pathway in gastric cancer

open access: yesMolecular Oncology, Volume 15, Issue 4, Page 1234-1255, April 2021., 2021
This study revealed that NKX2‐1‐AS1 might serve as an independent prognostic biomarker in gastric cancer (GC). NKX2‐1‐AS1 promotes cell proliferation and tumor angiogenesis in GC. Moreover, NKX2‐1‐AS1 directly targets miR‐145‐5p to upregulate SERPINE1 and promote tumor progression and angiogenesis in a VEGFR‐2‐dependent manner.
Fei Teng   +10 more
wiley   +1 more source

Automatic linear measurements of the fetal brain on MRI with deep neural networks [PDF]

open access: yes, 2021
Timely, accurate and reliable assessment of fetal brain development is essential to reduce short and long-term risks to fetus and mother. Fetal MRI is increasingly used for fetal brain assessment. Three key biometric linear measurements important for fetal brain evaluation are Cerebral Biparietal Diameter (CBD), Bone Biparietal Diameter (BBD), and ...
arxiv   +1 more source

A First Report on Experience in Managing Infants with Congenital Toxoplasmosis in Ethiopia: Case Reports and a Review of Evaluation and Treatment

open access: yesCase Reports in Infectious Diseases, Volume 2021, Issue 1, 2021., 2021
Background. Congenital toxoplasmosis is a major sequela of untreated primary maternal infection. With or without symptoms, untreated infections eventually lead to multiple neurologic complications. Despite the high Toxoplasma gondii seroprevalence in the Ethiopian population, there are no reports of newborns diagnosed and treated for congenital ...
Tinsae Alemayehu   +4 more
wiley   +1 more source

Hemolytic Disease of the Newborn: A Review of Current Trends and Prospects

open access: yesPediatric Health, Medicine and Therapeutics, 2021
Akshay Kiran Myle,1,2 Ghanim Hamid Al-Khattabi2 1Department of Clinical Research, General Medicine, Pharmacology, Integrative Medicine, Clinical Researcher.
Myle AK, Al-Khattabi GH
doaj  

Fetal oxygen delivery and consumption and blood gases in relation to gestational age [PDF]

open access: yesarXiv, 2021
Fetal oxygen delivery and consumption and blood gases in relation to gestational age. Oxygen crosses the placenta by diffusion and placental permeability to O$_2$ is high. Thus, the fetus receives adequate amounts, but vascular Po$_2$ is much lower than after birth. Studies of sustained fetal hypoxemia and acute 40-45% hemorrhage show that hypoxemia is
arxiv  

Fetal cardiovascular decompensation during labor predicted from the individual heart rate: a prospective study in fetal sheep near term and the impact of low sampling rate [PDF]

open access: yesFront. Pediatr. 2021, 2019
We present a novel computerized fetal heart rate intrapartum algorithm for early and individualized prediction of fetal cardiovascular decompensation, a key event in the causal chain leading to brain injury. This real-time machine learning algorithm performs well on noisy fetal heart rate data and requires ~2 hours to train on the individual fetal ...
arxiv   +1 more source

Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency [PDF]

open access: yes, 2000
The authors report a case of hydrops fetalis due to severe pyruvate kinase deficiency, the most unusual clinical manifestation of this disease. Conclusion Pyruvate kinase deficiency, as other erythrocyte enzymopathies, must be considered in the ...
Araújo, Filomena   +8 more
core   +1 more source

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