Results 111 to 120 of about 29,567 (256)

Primitive erythropoiesis in early chick embryogenesis. II. Correlation between hemoglobin synthesis and the mitotic history. [PDF]

, 1971
Primitive erythroblasts in the circulating blood of the chick embryo continue to divide while synthesizing hemoglobin (Hb). Hb measurements on successive generations of erythroblasts show that there is a progressive increase in the Hb content of both ...
Campbell, G le M, Holtzer, H, Mayall, BH, Weintraub, H   +3 more
core   +1 more source

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness [PDF]

, 2017
Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treating patients with sickle cell disease (SCD), produces anti-sickling effect by re-activating fetal γ-globin gene to enhance production of fetal hemoglobin ...
Choi, Jeong-Hyeon, Ganapathy, Vadivel, Ho, Meng Hsuan, Hu, Tianxiang, Kutlar, Abdullah, Kutlar, Ferdane, Patel, Niren, Pi, Wenhu, Tuan, Dorothy, Wang, Yongchao, Xu, Hongyan, Yu, Miao, Zhu, Xingguo   +12 more
core   +3 more sources

The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.

PLoS Biology, 2022
Nuclear envelope membrane proteins (NEMPs) are a conserved family of nuclear envelope (NE) proteins that reside within the inner nuclear membrane (INM). Even though Nemp1 knockout (KO) mice are overtly normal, they display a pronounced splenomegaly. This
Didier Hodzic, Jun Wu, Karen Krchma, Andrea Jurisicova, Yonit Tsatskis, Yijie Liu, Peng Ji, Kyunghee Choi, Helen McNeill   +8 more
doaj   +1 more source

Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts [PDF]

, 1979
The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20
Axel, R., Lacy, E., Maniatis, T., Silverstein, S., Wigler, M., Wold, B.   +5 more
core  

Cytochemical studies of the hemoglobin synthesis of erythroblasts [PDF]

, 1957
The process of hemoglobin sythesis in erythroid cells have been traced mainly by observing cells under the light of 4,060 Å. To scrutinize the theory of hemoglobin synthesis in the nucleus of erythroblasts, several cytochemical and morphological ...
Kubo, Yutaka, Oda, Takuzo, Okazaki, Hiroaki, Sakai, Akira, Seno, Satimaru, Tsuda, Shoji, Yoshizawa, Koyo   +6 more
core   +1 more source

Deep cytomorphology identifies erythroid skewing and monocytic morphology to predict TKI sensitivity in CML patients [PDF]

Hemasphere
Abstract The cellular composition of the chronic myeloid leukemia (CML) bone marrow (BM) beyond granulocyte enrichment remains poorly understood. We analyzed 1548 routinely stained BM aspirate slides from 598 patients across seven sites using deep learning‐based image analysis to identify cytomorphological markers predictive of major molecular response.
Luukkainen K, Purhonen M, Tatun M, Hung K, Tafjord O, Sundquist H, Söderlund S, Adnan‐Awad S, Dohlen A, Heikkinen J, Koskenvesa P, Joutsi‐Korhonen L, Lempiäinen A, Siitonen S, Mustjoki S, Shanmuganathan N, Bryce C, Danielsson S, Hjorth‐Hansen H, Olsson‐Strömberg U, Kumagai T, Kimura S, Ross D, Brück O.   +23 more
europepmc   +2 more sources

Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1, 2 and 5

PLoS ONE, 2015
In this study, we showed that adrenocorticotropic hormone (ACTH) promoted erythroblast differentiation and increased the enucleation ratio of erythroblasts.
E. Simamura, T. Arikawa, T. Ikeda, H. Shimada, H. Shoji, Hiroko Masuta, Yuriko Nakajima, H. Otani, H. Yonekura, T. Hatta   +9 more
semanticscholar   +1 more source

Clinical studies on iron metabolism of erythroblasts in preleukemic stage [PDF]

, 1974
The appearance of sideroblasts in hypoplastic anemia (HAl and acute myelocytic leukemia (AML), together with their sideroblastograms, was studied. Hematological studies on cases with type III sideroblast dominance by sideroblastograms produced the ...
Kimura, Ikuro, Sugiyama, Motoharu, Takahashi, lsao   +2 more
core   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

The miR-144/451 locus is required for erythroid homeostasis. [PDF]

, 2010
The process of erythropoiesis must be efficient and robust to supply the organism with red bloods cells both under condition of homeostasis and stress. The microRNA (miRNA) pathway was recently shown to regulate erythroid development.
Anton J. Enright, Baek, Bauer, Broudy, Bushati, Cei Abreu-Goodger, Cheloufi, Cifuentes, Daniel Bilbao-Cortes, Doench, Dolznig, Dore, Du, Du, Dónal O’Carroll, Giraldez, Gutiérrez, Hammond, Hutvágner, Kasper D. Rasmussen, Kingsley, Lewis, Lim, Lu, Marieke Von Lindern, Monica Di Giacomo, Nenad Bartonicek, O’Carroll, Papapetrou, Pase, Pfaffl, Pronk, Rastislav Horos, Salvatore Simmini, Schwenk, Selbach, Smyth, Socolovsky, van Dongen, von Lindern   +39 more
core   +2 more sources