Results 91 to 100 of about 23,516 (234)

The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation

Cell Reports, 2017
Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process.
Jeffrey Malik, Jacquelyn A. Lillis, Tyler Couch, Michael Getman, Laurie A. Steiner   +4 more
doaj   +1 more source

Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells

Stem Cell Reports, 2013
Summary The lack of knowledge about the mechanism of erythrocyte biogenesis through self-replication makes the in vitro generation of large quantities of cells difficult.
Sho-ichi Hirose, N. Takayama, Sou Nakamura, Kazumichi Nagasawa, Kiyosumi Ochi, S. Hirata, S. Yamazaki, Tomoyuki Yamaguchi, M. Otsu, Shinya Sano, Nobuyasu Takahashi, A. Sawaguchi, Mamoru Ito, Takashi Kato, H. Nakauchi, K. Eto   +15 more
semanticscholar   +1 more source

Isolation and characterization of orthochromatic erythroblasts.

, 2015
(A) Orthochromatic erythroblasts were isolated (gate highlighted in red) from the spleen by FACS (Aria II) based on their Ter119 versus CD44 expression. Hoechst negative cells were excluded from the sort.
Christina B. Wölwer (827149), Helen B. Pearson (267614), Nathan J. Godde (567811), Sarah M. Russell (136879), Patrick O. Humbert (136871), Kurt Lackovic (794766), Luke B. Pase (827150), David C. S. Huang (104376)   +7 more
core   +1 more source

Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts

Haematologica, 2013
Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely required for survival of late-stage definitive erythroid progenitors in the ...
Jeffrey Malik, A. R. Kim, Kaitlin A Tyre, Anjuli R. Cherukuri, J. Palis   +4 more
semanticscholar   +1 more source

Approximately half of the erythroblasts in maternal blood are of fetal origin [PDF]

, 2017
The enrichment of fetal erythroblasts from the peripheral blood of pregnant women is currently actively pursued for the development of a non-invasive means of prenatal diagnosis.
Holzgreve, W., Zhong, X.Y., Hahn, S., Troeger, C., Burgemeister, R., Minderer, S., Tercanli, S.   +6 more
core  

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Haematologica, 2010
Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji, Victor Yeh, Tzutzuy Ramirez, Maki Murata-Hori, Harvey F. Lodish   +4 more
doaj   +1 more source

Increased fetal erythroblasts in women who subsequently develop pre-eclampsia

, 2000
In pregnancies complicated by pre-eclampsia (PET) and/ or intrauterine growth restriction (IUGR) there is an increased number of fetal cells in the maternal circulation.
Nicolaides, K H, Al-Mufti, R, Hambley, H, Albaiges, G, Lees, C   +4 more
core   +1 more source

Studies on the iron metabolism of erythroblasts in various blood diseases [PDF]

, 1960
The serum iron contents and the number of sideroblasts from various patients and the radioactivity of erythroblasts from the same patients incubated with Fe55 have been observed.
Kodani, Ri-ichi, Kimura, Ikuro, Miyake, Tsuyoshi   +2 more
core   +1 more source

Characterization of the biophysical properties of human erythroblasts as a preliminary step to the isolation of fetal erythroblasts from maternal peripheral blood for non invasive prenatal genetic investigation

Haematologica, 1997
BACKGROUND AND OBJECTIVE: Fetal erythroblasts in maternal circulation represent a valuable source of fetal cell material which can be obtained with non-invasive procedures that do not endanger the fetus.
G Sitar, L Manenti, A Farina, V Lanati, P Mascheretti, A Forabosco, L Montanari, E Ascari   +7 more
doaj  

Erythroblastic islands: niches for erythropoiesis

Blood, 2008
AbstractErythroblastic islands, the specialized niches in which erythroid precursors proliferate, differentiate, and enucleate, were first described 50 years ago by analysis of transmission electron micrographs of bone marrow. These hematopoietic subcompartments are composed of erythroblasts surrounding a central macrophage. A hiatus of several decades
Joel Anne, Chasis, Narla, Mohandas
openaire   +3 more sources