Results 121 to 130 of about 29,567 (256)
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation
Cell Reports, 2017 Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process.
Jeffrey Malik +4 more
doaj +1 more source
PLoS Genetics, 2014 We have developed a new approach to characterize allele-specific timing of DNA replication genome-wide in human primary basophilic erythroblasts. We show that the two chromosome homologs replicate at the same time in about 88% of the genome and that ...
Rituparna Mukhopadhyay +11 more
semanticscholar +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
Studies on reticuloendothelial system and hematopoiesis. II. A study on the morphology and function of erythroblastic islet [PDF]
, 1965 1. For the purpose to clarify the role of reticuloendothelial cells in the center of erythroblastic islet, the medullary and extramedullary erythropoietic foci in convalescence of phenylhydrazine arternia were observed by light and electron microscopies,
Matsuoka, Kenichi
core +1 more source
A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System
Aging Cell, Volume 25, Issue 2, February 2026.Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White +9 more
wiley +1 more source
British Journal of Haematology, 2014 Human induced pluripotent stem cells (hiPSCs), like embryonic stem cells, are under intense investigation for novel approaches to model disease and for regenerative therapies. Here, we describe the derivation and characterization of hiPSCs from a variety
Cheng-Tao Yang +10 more
semanticscholar +1 more source
Formation of mammalian erythrocytes: chromatin condensation and enucleation [PDF]
, 2011 In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to ...
Ji, Peng +2 more
core +1 more source
International Journal of Laboratory Hematology, Volume 48, Issue 1, Page 12-25, February 2026.ABSTRACT Monocytes are key components of the Mononuclear Phagocyte System, crucial in immune defense, inflammation, and tissue repair. Accurate identification and classification of monocyte lineage cells are essential for diagnosing both reactive and clonal hematologic disorders.
Gina Zini +10 more
wiley +1 more source
Studies on erythropoiesis 1. Studies on cell size of erythroid cells from anemic animal [PDF]
, 1964 For the purpose to look into the regulatory mechanism of erythropoiesis, changes in the cell volume and the cell size of the erythroid cells have been observed in peripheral blood and marrow from normal and phenylhydrazine induced anemic rabbits. And the
Shibata, Takashi
core +1 more source