Results 131 to 140 of about 29,567 (256)

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

An Optimized Human Erythroblast Differentiation System Reveals Cholesterol‐Dependency of Robust Production of Cultured Red Blood Cells Ex Vivo

Advanced Science
The generation of cultured red blood cells (cRBCs) ex vivo represents a potentially unlimited source for RBC transfusion and other cell therapies. Human cRBCs can be generated from the terminal differentiation of proliferating erythroblasts derived from ...
Enyu Wang, Senquan Liu, Xinye Zhang, Qingyou Peng, Huijuan Yu, Lei Gao, An Xie, Ding Ma, Gang Zhao, Linzhao Cheng   +9 more
doaj   +1 more source

Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large‐scale diabetes registry J‐DREAMS

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 242-255, February 2026.
ABSTRACT Aims/Introduction This study aimed to identify clinical predictors associated with sustained decline in estimated glomerular filtration rate (eGFR) among Japanese individuals diagnosed with diabetes mellitus. Materials and Methods We conducted a retrospective analysis using J‐DREAMS (Japan Diabetes compREhensive database project based on an ...
Kota Yamada, Mitsuru Ohsugi, Yuichiro Ito, Hiroki Uchida, Takumi Lee, Kohjiro Ueki   +5 more
wiley   +1 more source

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Haematologica, 2010
Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji, Victor Yeh, Tzutzuy Ramirez, Maki Murata-Hori, Harvey F. Lodish   +4 more
doaj   +1 more source

Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts

Haematologica, 2013
Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely required for survival of late-stage definitive erythroid progenitors in the ...
Jeffrey Malik, A. R. Kim, Kaitlin A Tyre, Anjuli Cherukuri, J. Palis   +4 more
semanticscholar   +1 more source

Studies on the mechanism of supravital staining; supravital staining of blood cell nucleus [PDF]

, 1970
For the purpose to reveal the relation between cell death and nuclear stainability by supravital staining with basic dyes observations have been made on the cells of bone marrow, peripheral blood and lymph node from anemic and non-anemic rabbit, rat ...
Yoshii, Katsuko
core   +1 more source

The role of platelet microvesicles in intercellular communication. [PDF]

, 2016
In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core   +2 more sources

CD8+ T cell activation by murine erythroblasts infected with malaria parasites

Scientific Reports, 2013
Recent studies show that some human malaria parasite species Plasmodium falciparum and P.vivax parasitize erythroblasts; however, the biological and clinical significance of this is unclear. To investigate further, we generated a rodent malaria parasite (
T. Imai, H. Ishida, K. Suzue, M. Hirai, T. Taniguchi, H. Okada, Tomohisa Suzuki, C. Shimokawa, H. Hisaeda   +8 more
semanticscholar   +1 more source

Peripheral blood smear analysis: A comparison of GPT‐4o and supervised deep learning models

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Mobina Shrestha, Salina Dahal, Vishal Mandal, Amir Babu Shrestha   +3 more
wiley   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. I. Effects of aminopterin and bromouracil on hemopoiesis and hemoglobin synthesis in anemic rat [PDF]

, 1968
For the purpose to see how the suppression of the nucleic acid synthesis disturbs the cell specialization process the author observed the erythroid cell specialization in anemic rats by treating them with aminopterin (AP) and 5-bromouracil (BU).
Shigehisa, Morio
core   +1 more source