Results 181 to 190 of about 23,516 (234)

Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

open access: yesJournal of Experimental Medicine, 2022
In our study, we demonstrated the functional importance of intercellular mitochondria transfer to mediate bioenergetic profiles of recipient erythroblasts to facilitate their recovery from anemic stress.
Toshio Suda   +2 more
exaly   +2 more sources

BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells

open access: yesMolecular Therapy, 2021
Transfusion of red blood cells (RBCs) from ABO-matched but genetically unrelated donors is commonly used for treating anemia and acute blood loss. Increasing demand and insufficient supply for donor RBCs, especially those of universal blood types or free
Linzhao Cheng, Tong Chen, John Roback
exaly   +2 more sources

Approximately half of the erythroblasts in maternal blood are of fetal origin

open access: yesMolecular Human Reproduction, 1999
The enrichment of fetal erythroblasts from the peripheral blood of pregnant women is currently actively pursued for the development of a non-invasive means of prenatal diagnosis.
Sinuhe Hahn, C Troeger, X Y Zhong
exaly   +2 more sources

Characterization of first trimester fetal erythroblasts for non-invasive prenatal diagnosis

open access: yesMolecular Human Reproduction, 2003
Isolating fetal erythroblasts from first trimester maternal blood offers a promising non-invasive alternative for prenatal diagnosis. The aim of this study was to characterize the biological properties of first trimester primitive erythroblasts to ...
Mahesh Choolani   +2 more
exaly   +2 more sources

Excessive apoptosis of bone marrow erythroblasts in a patient with autoimmune haemolytic anaemia with reticulocytopenia

open access: yesBritish Journal of Haematology, 2000
We report a patient with autoimmune haemolytic anaemia (AIHA) with reticulocytopenia, who showed excessive apoptosis of erythroblasts. Ultrastructural analysis of bone marrow cells showed that 50% of erythroblasts had characteristic features of apoptosis,
A A van de Loosdrecht
exaly   +3 more sources

Erythroblastic islands in erythroleukemia

Journal of Pediatric Hematology/Oncology, 1981
Erythroblastic islands are distinct anatomical units allowing direct transfer of ferritin molecule into developing erythroblasts. A patient with Fanconi's anemia who developed acute erythroleukemia and hypotransferrinemia exhibited numerous erythroblastic islands in the bone marrow. This unusual finding in our patient is thought to be in response to an
A, Taher, E, Gilbert, N T, Shahidi
openaire   +2 more sources

Phenotypic heterogeneity of erythroblasts in erythroblastic leukemia revealed by monoclonal antibodies

American Journal of Hematology, 1988
AbstractEight cases each of erythroleukemia (AML‐M6) and erythroblastic crisis of chronic granulocytic leukemia (CGLBC‐E) were immunophenotyped with the help of a panel of lineage‐associated monoclonal antibodies (McAbs). The latter included those reactive with erythroid progenitor (BFU‐E and CFU‐E) and erythroid precursors at different stages of ...
A D, Gupta, S R, Dhond
openaire   +2 more sources

Humanized Culture Medium for Clinical Expansion of Human Erythroblasts [PDF]

open access: yesCell Transplantation, 2010
Ex vivo-generated erythroblasts represent alternative transfusion products. However, inclusion of bovine components in media used for their growth precludes clinical use, highlighting the importance of developing culture media based on pharmaceutical ...
Valentina Tirelli   +2 more
exaly   +2 more sources

Enucleation of human erythroblasts involves non-muscle myosin IIB

open access: yesBlood, 2012
Mammalian erythroblasts undergo enucleation, a process thought to be similar to cytokinesis. Although an assemblage of actin, non-muscle myosin II, and several other proteins is crucial for proper cytokinesis, the role of non-muscle myosin II in ...
Wataru Nunomura
exaly   +2 more sources

Downregulation of intrinsic apoptosis pathway in erythroblasts contributes to excessive erythrocytosis of chronic mountain sickness.

Blood Cells, Molecules & Diseases, 2019
Chronic mountain sickness (CMS) has a higher incidence in the plateau region and is characterized by excessive erythrocytosis and hypoxemia. Bcl-2 family plays an important role in the process of erythropoiesis and the regulation of apoptosis. This study
Jie Ma   +8 more
semanticscholar   +1 more source

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