Results 51 to 60 of about 45,398 (287)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Hemorheology and hemostasis in ischemic stroke patients treated with i.v. thrombolysis

Анналы клинической и экспериментальной неврологии, 2017
Hemostatic and hemorheological dysregulations are the typicalpathological conditions in stroke. Thorough dynamic examinationsof hemostasis, platelet aggregation, kinetics of erythrocyteaggregation/disaggregation along with clinical and ...
M. E. Gafarova, M. A. Domashenko, D. Z. Korobkova, M. Yu. Maximova, M. A. Loskutnikov, A. A. Shabalina, M. V. Kostyreva, R. N. Konovalov   +7 more
doaj   +1 more source

A PRELIMINARY STUDY OF THE EFFECT OF ANESTHETIC AGENTS ON THERHEOLOGICAL PARAMETERS OF GLYCATED ERYTHROCYTES

Anales (Asociación Física Argentina), 2021
This paper presents a preliminary study of the effects of the anesthetics propofol, remifentanil, and vecuronium bromideon the rheological properties of glycated erythrocytes in vitro, modeling the glycation by hyperglycemia observed in ...
M. V. Batista da Silva, H. Castellini, N. A. Alet, B. Riquelme, A. I. Alet   +4 more
doaj   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Erythrocyte aggregation: Basic aspects and clinical importance

Clinical Hemorheology and Microcirculation, 2013
Red blood cell (RBC) aggregate to form two- and three-dimensional structures when suspended in aqueous solutions containing large plasma proteins or polymers; this aggregation is reversible and shear dependent (i.e., dispersed at high shear and reformed at low or stasis).
Oguz K, Baskurt, Herbert J, Meiselman
openaire   +5 more sources

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Blood rheological properties and methods of their measurement

Annales Academiae Medicae Silesiensis
From the physical point of view, blood is a multi-phase and multi-component system; plasma is the dispersion medium and the morphotic elements are the dispersed phase.
Tomasz Pryzwan, Patrycja Dolibog, Klaudia Kierszniok, Barbara Pietrzyk   +3 more
doaj   +1 more source

Hemocompatibility of magnetic magnethite nanoparticles and magnetite-silica composites in vitro

Бюллетень сибирской медицины, 2018
The goal of the present research is to study the hemocompatibility of magnetic nanoparticles (MNPs)  in model systems in vitro.Materials and methods. Magnetite nanoparticles and magnetite colloidal solutions were used in 0.9% NaCl in concentrations 0.2 ...
Y. G. Toropova, N. A. Pechnikova, I. A. Zelinskaya, D. V. Korolev, K. G. Gareev, А. S. Markitantova, V. D. Bogushevskaya, A. V. Povolotskaya, A. A. Manshina   +8 more
doaj   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source