Results 51 to 60 of about 45,210 (324)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Physical and chemical processes and the morphofunctional characteristics of human erythrocytes in hyperglycaemia [PDF]

, 2017
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the ...
Bourdon, Jean Christophe, Gromova, Natalia V., Grunyushkin, Igor P., Klenova, Natalia A., Pestryakova, Anastasia A., Prosnikova, Ksenia V., Revin, Victor V., Revina, Elvira S., Sadykhova, Anna V., Solomadin, Ilia N., Tychkov, Alexander Y., Zhelev, Nikolai   +11 more
core   +4 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Blood rheological properties and methods of their measurement

Annales Academiae Medicae Silesiensis
From the physical point of view, blood is a multi-phase and multi-component system; plasma is the dispersion medium and the morphotic elements are the dispersed phase.
Tomasz Pryzwan, Patrycja Dolibog, Klaudia Kierszniok, Barbara Pietrzyk   +3 more
doaj   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Hemorheology and hemostasis in ischemic stroke patients treated with i.v. thrombolysis

Анналы клинической и экспериментальной неврологии, 2017
Hemostatic and hemorheological dysregulations are the typicalpathological conditions in stroke. Thorough dynamic examinationsof hemostasis, platelet aggregation, kinetics of erythrocyteaggregation/disaggregation along with clinical and ...
M. E. Gafarova, M. A. Domashenko, D. Z. Korobkova, M. Yu. Maximova, M. A. Loskutnikov, A. A. Shabalina, M. V. Kostyreva, R. N. Konovalov   +7 more
doaj   +1 more source

Hydrogen Gas Inhalation Prevents Erythrocyte Aggregation and Promotes Leukocyte Phagocytosis Together with Increases in Serum Antioxidant Activity

Hydrogen, 2022
Hydrogen gas inhalation has not yet been elucidated to improve blood behaviors or antioxidant activity in blood. In the present study, the PEM (proton-exchange-membrane)-/platinum-plated electrode-equipped electrolyzer was examined as a hydrogen gas ...
Yuki Takada, Nobuhiko Miwa
doaj   +1 more source

The ₉₅RGD₉₇ sequence on the A alpha chain of fibrinogen is essential for binding to its erythrocyte receptor [PDF]

, 2018
Background: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen mutations on binding to its human erythrocyte receptor was assessed in order to identify the ...
Ariens, RAS, Carvalho, FA, Duval, C, Farrell, DH, Guedes, AF, Macrae, FL, Santos, NC, Swithenbank, L   +7 more
core   +2 more sources

Association Between Sleep Disturbance and Subsequent Pain Interference in Patients With Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated whether sleep disturbance can predict the extent to which pain interferes with daily functioning in patients with early rheumatoid arthritis (RA). Methods Data were from adults with early RA (joint symptoms ≤12 months) enrolled in the Canadian Early Arthritis Cohort between 2016 and 2023.
Burcu Aydemir, Orit Schieir, Marie‐France Valois, Lutfiyya N. Muhammad, Jing Song, Dorothy Dunlop, Rowland W. Chang, Susan J. Bartlett, Louis Bessette, Gilles Boire, Glen Hazlewood, Carol Hitchon, Janet Pope, Carter Thorne, Diane Tin, Vivian P. Bykerk, Yvonne C. Lee   +16 more
wiley   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source