Results 31 to 40 of about 825,332 (294)

Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol

Cardiovascular Therapeutics, 2020
Objectives. Several beneficial effects of resveratrol have already been published. This study evaluated the effect of resveratrol on the hemorheological parameters in patients with heart failure with reduced ejection fraction. Methods.
Roland Gal, Dora Praksch, Peter Kenyeres, Miklos Rabai, Kalman Toth, Robert Halmosi, Tamas Habon   +6 more
doaj   +1 more source

The relationship of microcirculation parameters of the bulbar conjunctiva and coronary angiography in patients with coronary artery disease

Российский кардиологический журнал, 2019
Aim. To identify the associations between microcirculation parameters obtained using the method of bulbar conjunctiva videobiomicroscopy and coronary angiography in patients with acute coronary syndrome (ACS).Material and methods. Fifty six patients with
N. V. Korneeva, B. Z. Syrotin, N. V. Bondar, V. Ya. Rudman   +3 more
doaj   +1 more source

Evolution of erythrocytes aggregation: A fractal approach when incubated with Trichinella spiralis and Ascaris lumbricoides

Ain Shams Engineering Journal, 2018
Fractal geometry has provided a new range of concepts that could explain the non-linear behaviour of seemingly unpredictable natural systems. The aim of this work is to apply nonlinear analysis to study the in vitro erythrocyte aggregation produced by ...
Maela Lupo, Alcides J. Leguto, Santiago A. Bortolato, Ana M. Korol   +3 more
doaj   +1 more source

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Size-dependent aggregation of erythrocytes by low molecular weight hyaluronic acids of different sizes: bioactivity and quality control potential

Frontiers in Physiology
IntroductionHyaluronic acid (HA) is a crucial biological molecule whose diverse functions are strongly influenced by its molecular weight. In particular, low molecular weight HA (LMW-HA) fragments—such as HA60 (average 60 kDa), HA35 (average 35 kDa), and
Xinyue Ma, Xiao Wang, XiaoXiao Jia, Jessica H. Hui, Joshua H. Shofaro, Ran Tao, Mizhou Matthew Hui   +6 more
doaj   +1 more source

Platelet lipid composition and platelet aggregation in human liver disease

Journal of Lipid Research, 1981
Abnormal plasma lipoproteins in patients with liver disease are associated with an increase in erythrocyte cholesterol concentration and a raised erythrocyte cholesterol/phospholipid molar ratio.
J S Owen, R A Hutton, R C Day, K R Bruckdorfer, N McIntyre   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

EVALUATION OF THE HEMOCOMPATIBILITY OF NANOSTRUCTURES ON IN VITRO MODEL SYSTEMS

Siberian Journal of Life Sciences and Agriculture
Background. An important issue in the evaluation of nanoparticles is the manifestation of test objects that allow the evaluation of damaging effects in vitro. Purpose.
Elena V. Nevzorova, Viktoriya V. Nemtsova, Anton A. Belyaev   +2 more
doaj   +1 more source