Results 141 to 150 of about 46,095 (333)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Physiological Peculiarities of Erythrocytes’ Rheological Characteristics in Persons of the Second Mature Age at the Start of Regular Exercises after Lasting Hypodynamia

, 2018
N.V. Vorobyeva, Elena V. Skripleva, A Skriplev, Tatiana V. Skoblikova   +3 more
openalex   +1 more source

Oxidative Protein Damage Is Associated With Severe Functional Dependence Among the Elderly Population: A Principal Component Analysis Approach [PDF]

, 2013
Background. Studies of the role of oxidative stress in functional dependence among the aging population are limited. In this report, we address this situation through an analysis of a large panel of blood oxidative biomarkers in elderly population ...
Gonzalo-Calvo, David
core  

Aging and erythrocyte sorbitol.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1987
M. Funasako, A. Samukawa, K. Nishio, M. Tanichi, N. Sunda, Y. Nakai, S. Kobayashi, A. Kakutani, O. Nishikawa, H. Sunda, A. Ota, Y. Sakagami, M. Ohata   +12 more
openaire   +3 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Glycated Hemoglobin, Plasma Glucose, and Erythrocyte Aging. [PDF]

J Diabetes Sci Technol, 2016
Beltran Del Rio M, Tiwari M, Amodu LI, Cagliani J, Rodriguez Rilo HL.   +4 more
europepmc   +1 more source

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes [PDF]

, 2003
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated.
Asin-Cayuela, Jordi, Attardi, Giuseppe, Bonafé, Massimiliano, De Benedictis, Giovanna, Fish, Jennifer, Franceschi, Claudio, Michikawa, Yuichi, Olivieri, Fabiola, Passarino, Giuseppe, Zhang, Jin   +9 more
core  

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Physiological Features of Erythrocytes in the Aging Organism [PDF]

, 2023
Elena Tkacheva, И. Н. Медведев, N.V. Vorobyeva, Valerii Panteleevich Kartashev, G. S. Mal   +4 more
openalex   +1 more source