Results 51 to 60 of about 46,095 (333)

The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations

Cells, 2022
The proclivity of certain pre-malignant and pre-invasive breast lesions to progress while others do not continues to perplex clinicians. Clinicians remain at a crossroads with effectively managing the high-risk patient subpopulation owing to the paucity ...
Nikita Jinna, Padmashree Rida, Tianyi Su, Zhihong Gong, Song Yao, Mark LaBarge, Rama Natarajan, Tijana Jovanovic-Talisman, Christine Ambrosone, Victoria Seewaldt   +9 more
doaj   +1 more source

Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period [PDF]

, 2019
BACKGROUND: Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies.
Backhaus, Marina, Burmester, Gerd-Rüdiger, Glimm, Anne-Marie, Haugen, Ida Kristin, Hermann, Sandra, Hoff, Paula, Häupl, Thomas, Le, Lien, Mansmann, Ulrich, Ohrndorf, Sarah, Sprenger, Lisa Ines   +10 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Blood Volume, Hemoglobin Mass, and Peak Oxygen Uptake in Older Adults: The Generation 100 Study

Frontiers in Sports and Active Living, 2021
Purpose: To investigate the association between blood volume, hemoglobin mass (Hbmass), and peak oxygen uptake (VO2peak) in healthy older adults.Methods: Fifty fit or unfit participants from the prospective randomized Generation 100 Study (n = 1,566 ...
Kari Margrethe Lundgren, Nils Petter Aspvik, Knut Asbjørn Rise Langlo, Tonje Braaten, Tonje Braaten, Ulrik Wisløff, Ulrik Wisløff, Dorthe Stensvold, Trine Karlsen, Trine Karlsen   +9 more
doaj   +1 more source

Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters [PDF]

, 2008
Background: The chemical inertness of hydroxyethyl starch (HES) might cause interferences of the colloid with a variety of laboratory tests. We aimed to evaluate potential influences of HES 130/0.4, the newest HES type, on several common hematology and ...
Dieplinger, Benjamin, Haltmayer, Meinhard, Kreimeier, Uwe, Loeffler, Peter, Mueller, Thomas, Poelz, Werner, Rehm, Markus, Schimetta, Wolfgang   +7 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Numerical Model for the Determination of Erythrocyte Mechanical Properties and Wall Shear Stress in vivo From Intravital Microscopy. [PDF]

, 2019
The mechanical properties and deformability of Red Blood Cells (RBCs) are important determinants of blood rheology and microvascular hemodynamics. The objective of this study is to quantify the mechanical properties and wall shear stress experienced by ...
Cabrales, Pedro, Jani, Vinay P, Jani, Vivek P, Lucas, Alfredo, Munoz, Carlos, Ortiz, Daniel, Williams, Alexander T, Yalcin, Ozlem   +7 more
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory parameters

Frontiers in Medicine
IntroductionThe aging process is frequently associated with a decline in functional capacity, endurance, muscle quality, and overall quality of life. Examining aging-related biomarkers often requires significant time and financial resources, underscoring
Nina Kemala Sari, Stepvia Stepvia, Muhana Fawwazy Ilyas, Siti Setiati, Siti Setiati, Kuntjoro Harimurti, Ika Fitriana   +6 more
doaj   +1 more source