Results 111 to 120 of about 24,129 (300)

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Validity of Erythrocyte Indices in Differentiation between Iron Deficiency Anemia and β-Thalassemia Trait in Children

The Journal of Pediatric Academy
Iron deficiency anemia (IDA) and β-thalassemia trait (BTT) are the most common causes of hypochromic microcytic anemia (HMA). Various erythrocyte indices that may help in the initial discrimination between IDA and BTT have been reported, but data ...
Emel Uzunoğlu, Ebru Yılmaz Keskin
doaj   +1 more source

LOOKING BACK TO OUR ROOTS: 80 YEARS OF WINTROBE’S INDICES [PDF]

European Medical Journal Hematology, 2014
This year (2014) we are celebrating the 80th anniversary of Dr Maxwell Myer Wintrobe’s pioneer works, one of the most important contributions in clinical laboratory and medicine.
Eloísa Urrechaga, Silvia Izquierdo, Jesús F. Escanero   +2 more
doaj  

Erythrocyte indices of iron status in children with cyanotic congenital heart disease at the University College Hospital, Ibadan

, 2012
Background Iron (Fe) deficiency is a known feature of cyanotic congenital heart disease (CCHD) and may worsen symptoms. The prevalence of iron deficiency among children with CCHD at the University College Hospital (UCH), Ibadan is unknown.
Ogunkunle, OO
core   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Clinical Factors Associated With Non‐Completion of Durvalumab Maintenance Therapy After Chemoradiotherapy in Patients With Locally Advanced Non‐Small Cell Lung Cancer: A Single‐Center Retrospective Study

Thoracic Cancer
Background Durvalumab maintenance following concurrent chemoradiotherapy (CCRT) is the standard treatment for unresectable stage III non‐small cell lung cancer (NSCLC); however, some patients discontinue treatment before completing 12 months. We explored
Masaaki Kotake, Satoshi Watanabe, Yuki Sakai, Toshiaki Kikuchi, Akira Toyama   +4 more
doaj   +1 more source

Erythrocyte voltage-dependent calcium influx is reduced in hemodialyzed patients

, 1999
Erythrocyte voltage-dependent calcium influx is reduced in hemodialyzed patients.BackgroundUremia displays increased cytosolic free calcium ([Ca2+]i) in many different cell types, supporting the hypothesis of an altered Ca2+ transport modifying the ...
Soldati, Laura, A. Caumo, D. Adamo, Zerbi, Simona, Bianchi, Giuseppe, L. Soldati, Spaventa, Renato, Caumo, Andrea, Adamo, Donatella, G. Vezzoli, G. Bianchi, S. Zerbi, Vezzoli, Giuseppe, R. Spaventa   +13 more
core   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

PROTEIN-LIPID COMPOSITION OF ERYTHROCYTE MEMBRANES AND METABOLISM IN CHRONIC ENDOMETRITIS

, 2017
Background: Establishment of changes in protein-lipid spectrum of erythrocyte’s membrane in CE before and after traditional complex treatment. Materials and methods: At 38 patients in reproductive age with verified diagnosis of chronic endometritis in ...
Konoplya, Nikolay, Olga Anatolyevna Sunyakina, Svetlana Leonidovna Sergeeva, Sergeeva, Svetlana, Barsuk, Anna, Anna Alexandrovna Barsuk, Sunyakina, Olga, Nikolay Alexandrovich Konoplya   +7 more
core   +1 more source