Results 61 to 70 of about 1,239,207 (305)

Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits

Biomedical Papers, 2016
Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa ...
Lucie Sulovska, Dusan Holub, Zuzana Zidova, Martina Divoka, Marian Hajduch, Vladimir Mihal, Jana Vrbkova, Monika Horvathova, Dagmar Pospisilova   +8 more
doaj   +1 more source

The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets [PDF]

, 2016
Peptidoglycan is the major component of the cell envelope of virtually all bacteria. It has structural roles and acts as a selective sieve for molecules from the outer environment. Peptidoglycan synthesis is therefore one of the most important biogenesis
Eefjan Breukink, Liu, Yao, Breukink, Eefjan, Yao Liu, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics   +5 more
core   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Eryptotic Phenotype in Chronic Myeloid Leukemia: Contribution of Neutrophilic Cathepsin G

Anemia, 2012
In pathological conditions with concurrent neutrophilia, modifications of erythrocyte membrane proteins are reported. In chronic myeloid leukemia (CML), a myeloproliferative disease wherein neutrophilia is accompanied by enhanced erythrophagocytosis, we ...
Rukmini Govekar, Poonam Kawle, Renjan Thomas, Suresh Advani, Sheena PV, Surekha Zingde   +5 more
doaj   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Mechanism of hypoxia-induced damage to the mechanical property in human erythrocytes—band 3 phosphorylation and sulfhydryl oxidation of membrane proteins

Frontiers in Physiology
Introduction: The integrity of the erythrocyte membrane cytoskeletal network controls the morphology, specific surface area, material exchange, and state of erythrocytes in the blood circulation.
Qinqin Yang, Dong Chen, Chungong Li, Runjing Liu, Xiang Wang   +4 more
doaj   +1 more source

The increased erythrocyte membrane n-6/n-3 fatty acids ratio and inflammatory markers in patients with psoriasis

Indian Journal of Rheumatology, 2019
Background: Psoriasis is a common chronic, recurrent inflammatory skin disorder. Omega-3 fatty acids exhibit low inflammatory effects, while n-6 fatty acids display high inflammatory effects.
Serap Ozer Yaman, Asım Orem, Fulya Balaban Yucesan, Savas Yayli, Sadık Ozturk, Sevgi Bahadir   +5 more
doaj   +1 more source

Erythrocyte aggregation and metabolic syndrome

, 2014
Erythrocyte aggregation has been consistently associated with insulin resistance, central obesity and hypertension in the literature. Oxidative stress and chronic inflammation are almost always present in metabolic syndrome (MetS).
Tinley, Paul, Hughes, Diane L., Richards, Ross S., Gyawali, Prajwal   +3 more
core   +1 more source

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. [PDF]

, 2014
Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P.
Conway, David J, Conway, David J., Ollomo, Benjamin, Ollomo, B., Böhme, Ulrike, Berriman, Matthew, Thomas, A. W., Bohme, U., Rayner, Julian C., Otto, Thomas D, Rayner, Julian C, Otto, Thomas D., Spottiswoode, N., Newbold, C., Otto, T. D., Pain, A., Pain, Arnab, Thomas, Alan W., Rayner, J. C., Berriman, M., Sanders, M., Conway, D. J., Renaud, F., Sanders, Mandy, Quail, Michael, Renaud, François, Quail, M., Thomas, Alan W, Spottiswoode, Natasha, Newbold, Chris, Prugnolle, Franck   +30 more
core   +1 more source